{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:01:30Z","timestamp":1790060490941,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Thymically\u2010derived regulatory T (Treg) cells express the transcription factor Foxp3 and are maintained at homeostasis by the cytokine IL\u20102. These specialized cells mediate peripheral tolerance and determine the balance between protective and pathological T cell responses during infection. Acute infection of mice with\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    results in thymic atrophy and reduced production of IL\u20102 that correlate with a \u201ccrash\u201d in Treg cell populations. Here, kinetic studies of mice infected with\n                    <jats:italic>T. gondii<\/jats:italic>\n                    reveal that as acute infection resolves, there is a restoration of IL\u20102 and reversal of thymic hypertrophy associated with partial restoration of the Treg compartment. Fate\u2010mapping of the Treg cell compartment showed that infection\u2010induced thymic involution did not severely impact the ability to generate Treg cells. Moreover, the peripheral Treg cells that survived the infection\u2010induced \u201ccrash\u201d were the major contributors to the rebuilt Treg compartment. However, the use of antiparasitic drugs to reduce chronic parasite replication and inflammation improved generation of thymic Treg cells that contributed to the rebuilding of the Treg cell pool. These studies illustrate that infection\u2010induced loss of IL\u20102 and Treg cells is transient, and despite the ability to generate thymically derived Treg cells, those peripheral Treg cells that survive the acute \u201ccrash\u201d are preferentially maintained.\n                  <\/jats:p>","DOI":"10.1002\/eji.70265","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:04:13Z","timestamp":1787209453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Chronic Infection\u2010Induced Inflammation on TREG Cell Homeostasis"],"prefix":"10.1002","volume":"56","author":[{"given":"Zachary R.","family":"Lanzar","sequence":"first","affiliation":[{"name":"Department of Pathobiology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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