{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:01:53Z","timestamp":1790060513249,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Regulatory T (Treg) cells are central mediators of immune tolerance and are generally considered to rely predominantly on mitochondrial metabolism rather than glucose\u2010driven glycolysis. To define the role of glucose metabolism in Treg cells, we investigated the contribution of the hexose transporters GLUT1 and GLUT3. Genetic ablation of GLUT1 in T cells or selectively in Treg cells had minimal impact on Treg cell numbers, phenotype, or immune homeostasis, indicating that GLUT1 is largely dispensable in this lineage. By contrast, deletion of GLUT3 in T cells resulted in a marked reduction in Treg cell numbers. However, it remained unclear whether this reduction reflected diminished IL\u20102 production by GLUT3\u2010deficient conventional T cells or a cell\u2010intrinsic requirement for GLUT3 in Treg cells. To investigate this, we generated mice with Treg cell\u2010specific deletion of GLUT3. These animals developed severe systemic inflammation accompanied by lethal cellular and humoral autoimmunity. Mechanistically, GLUT3\u2010deficient Treg cells exhibited reduced glycolytic activity and mitochondrial respiration, leading to impaired suppressive function and defective effector and follicular Treg cell differentiation. Collectively, our findings demonstrate a nonredundant requirement for GLUT3 in Treg cell metabolic fitness and immune regulation, refining the prevailing view that Treg cells operate largely independently of glucose metabolism. Our data further suggest that therapeutic strategies targeting glucose uptake and glycolysis in autoimmune and inflammatory diseases should account for potential adverse effects on Treg cell\u2010mediated immune tolerance.<\/jats:p>","DOI":"10.1002\/eji.70272","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:52:23Z","timestamp":1787575943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Glucose Transporter GLUT3 Controls Regulatory T Cell Function"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5841-2398","authenticated-orcid":false,"given":"Katrin","family":"Sinning","sequence":"first","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Eckstein","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5253-1784","authenticated-orcid":false,"given":"Alexandra","family":"Freitag","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Rosenfeldt","sequence":"additional","affiliation":[{"name":"Institute of Pathology Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-4170","authenticated-orcid":false,"given":"Sophia M.","family":"Hochrein","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-7052","authenticated-orcid":false,"given":"Martin","family":"Vaeth","sequence":"additional","affiliation":[{"name":"W\u00fcrzburg Institute of Systems Immunology Max Planck Research Group Julius\u2010Maximilians\u2010University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq1405"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05543"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"1379","article-title":"X\u2010linked Lymphoreticular Disease in the Scurfy (sf) Mutant Mouse","volume":"138","author":"Godfrey V. 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