{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:49:56Z","timestamp":1792039796746,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["490846870 CRC\/TRR 355\/1 A04"],"award-info":[{"award-number":["490846870 CRC\/TRR 355\/1 A04"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["490846870 CRC\/TRR 355\/1 B08"],"award-info":[{"award-number":["490846870 CRC\/TRR 355\/1 B08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["318346496 CRC 1292 TP18"],"award-info":[{"award-number":["318346496 CRC 1292 TP18"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1292 TP22"],"award-info":[{"award-number":["CRC 1292 TP22"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TPQ1"],"award-info":[{"award-number":["TPQ1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Immunol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Regulatory T cells (Tregs) are essential for immune tolerance, with cAMP metabolism central to their suppressive function. Inducible cAMP early repressor (ICER) is a negative regulator of cAMP signalling. However, its role in Treg biology is not fully understood. Here we generated Foxp3\u2010specific ICER knockout mice to assess ICER's function in Tregs. We found that ICER deficiency does not impair Treg development or suppression of effector T cell proliferation under homeostatic conditions. However, ICER\u2010deficient Tregs display enhanced Foxp3 stability, increased glycolysis and proliferation but exhibit impaired suppression of IFN\u2010\u03b3 production by effector T cells. In a dextran sodium sulphate\u2010induced colitis model, loss of ICER in Tregs led to aggravated intestinal inflammation and tissue damage, without, however, a marked effect on gross disease parameters. These results identify ICER as a context\u2010dependent modulator of Treg metabolism and inflammatory cytokine control, highlighting its potential role in regulating immune responses during inflammation.<\/jats:p>","DOI":"10.1002\/eji.70297","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:42:34Z","timestamp":1792039354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis"],"prefix":"10.1002","volume":"56","author":[{"given":"Aleksandra","family":"Lopez Krol","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele C.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie M.","family":"Oberwalder","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitikk","family":"Chawla","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Alberto Barbosa","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Center for Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Boukhallouk","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Romero","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hausen","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias M.","family":"Gaida","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Mainz  Mainz Germany"},{"name":"Translational Oncology at the University Medical Center Mainz (TRON)  Mainz Germany"},{"name":"Research Center for Immunotherapy (FZI), University Medical Center Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Berod","sequence":"additional","affiliation":[{"name":"Research Center for Immunotherapy (FZI), University Medical Center Johannes Gutenberg\u2010University Mainz  Mainz Germany"},{"name":"Institute of Molecular Medicine University Medical Center of the Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Alves\u2010Filho","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Center for Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Sparwasser","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Research Center for Immunotherapy (FZI), University Medical Center Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1002\/eji.202049123","article-title":"Mechanisms of exTreg Induction","volume":"51","author":"Saxena V.","year":"2021","journal-title":"European Journal of Immunology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2017.05.005","article-title":"Interferon\u2010\u03b3 Drives Treg Fragility to Promote Anti\u2010Tumor Immunity","volume":"169","author":"Overacre\u2010Delgoffe A. 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Z.","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cmet.2016.12.018","article-title":"Foxp3 Reprograms T Cell Metabolism to Function in Low\u2010Glucose, High\u2010Lactate Environments","volume":"25","author":"Angelin A.","year":"2017","journal-title":"Cell Metabolism"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ni.3076","article-title":"Treg Cells Require the Phosphatase PTEN to Restrain TH1 and TFH Cell Responses","volume":"16","author":"Shrestha S.","year":"2015","journal-title":"Nature Immunology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948052","article-title":"Mitochondrial Transfer From MSCs to T Cells Induces Treg Differentiation and Restricts Inflammatory Response","volume":"21","author":"Court A. 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J.","year":"2018","journal-title":"Frontiers in Neural Circuits"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130242","article-title":"A2A R Mediated Modulation in IP3 Levels Altering the [Ca2+]i Through cAMP\u2010Dependent PKA Signalling Pathway","volume":"1866","author":"Barodia S. 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