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ZFs contain small domains made up of a combination of four cysteine and histidine residues and are classified on the basis of the identity of these residues and their spacing. One emerging class of ZFs are the Cys<jats:sub>3<\/jats:sub>His (or CCCH) class of ZFs. These ZFs play key roles in regulating RNA. In this minireview, an overview of the CCCH class of ZFs, with a focus on tristetraprolin (TTP), is provided. TTP regulates inflammation by controlling cytokine mRNAs, and there is an interest in modulating TTP activity to control inflammation. Two methods to control TTP activity are to target with exogenous metals (a \u201cmetals in medicine\u201d approach) or to target with endogenous signaling molecules. Work that has been done to target TTP with Fe, Cu, Cd, and Au as well as with H<jats:sub>2<\/jats:sub>S is reviewed. This includes attention to new methods that have been developed to monitor metal exchange with the spectroscopically silent Zn<jats:sup>II<\/jats:sup> including native electro\u2010spray ionization mass spectrometry (ESI\u2010MS), spin\u2010filter inductively coupled plasma mass spectrometry (ICP\u2010MS), and cryo\u2010electro\u2010spray mass spectrometry (CSI\u2010MS); along with fluorescence anisotropy (FA) to follow RNA binding.<\/jats:p>","DOI":"10.1002\/ejic.202100402","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T06:49:17Z","timestamp":1626850157000},"page":"3795-3805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Targeting Zinc Finger Proteins with Exogenous Metals and Molecules: Lessons Learned from Tristetraprolin, a CCCH type Zinc Finger"],"prefix":"10.1002","volume":"2021","author":[{"given":"Kiwon","family":"Ok","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Maryland School of Pharmacy  Baltimore MD 21201 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos R.","family":"Filipovic","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Analytische Wissenschaften-ISAS-e.V.  44227 Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2453","authenticated-orcid":false,"given":"Sarah L. 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