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Males of mantellid frogs from Madagascar and hyperoliid frogs from Africa emit complex, species\u2010 and sex\u2010specific bouquets of volatiles from their femoral or gular glands. We report here on the identification, synthesis, and determination of the absolute configuration of a macrocyclic lactone occurring in several species of both families, (<jats:italic>S<\/jats:italic>)\u20103,7,11\u2010dodec\u20106,10\u2010dien\u201012\u2010olide (<jats:italic>S<\/jats:italic>\u2010<jats:bold>14<\/jats:bold>, frogolide). Macrolides are a preferred compound class of frog volatiles. 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