{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:49:39Z","timestamp":1777441779628,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic pain patients with sensitization may exhibit decreased sensitivity to normally pruritogenic sensory stimuli and moreover occasionally perceive these as painful. This study explored the relationship between itch and pain, by evaluating histaminergic and non\u2010histaminergic itch evoked in capsaicin\u2010induced allodynic and hyperalgesic areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 28 healthy volunteers, capsaicin (100\u00a0\u03bcg\/0.1\u00a0mL) was injected intradermally in the volar forearm to establish secondary dysesthesias. After the capsaicin\u2010induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10\u00a0mg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) and cowhage (25\u201340 spicules). The evoked itch and pain were recorded on a visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>0\u201310\u00a0cm). Contralateral injection of 0.1\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>isotonic saline served as a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histaminergic and non\u2010histaminergic evoked itch were significantly decreased when provoked in allodynic skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The area\u2010under\u2010the\u2010curve of the evoked itch was reduced \u221243% from 18.0\u00a0\u00b1\u00a02.6\u00a0cm<jats:sup>10\u00a0min<\/jats:sup>in normal skin to 10.3\u00a0\u00b1\u00a01.8\u00a0cm<jats:sup>10\u00a0min<\/jats:sup>in allodynic skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) for cowhage and \u221256% from 20.0\u00a0\u00b1\u00a03.5\u00a0cm<jats:sup>10\u00a0min<\/jats:sup>in normal skin to 8.8\u00a0\u00b1\u00a02.3\u00a0cm<jats:sup>10\u00a0min<\/jats:sup>allodynic skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) for histamine. The pain responses to the pruritogens were not significantly altered between the areas of allodynia and normal skin (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.1). An additional experiment showed that pinprick hyperalgesia in the absence of allodynia was sufficient to evoke the observed reduced sensitivity to itch stimuli.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous sensitization (secondary allodynia and hyperalgesia) reduced itch responses regardless of the type of itch model applied and without attenuation of the associated pruritogen\u2010induced pain responses. This could explain the decreased sensitivity to itch provocations previously observed in patients with chronic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study shows that the neuronal sensitization processes underlying the development secondary hyperalgesia involve significant gating of histaminergic as well as non\u2010histaminergic pruriceptive transmission. Because these itch provocations normally target specific subpopulations of C\u2010nociceptors they could be of relevance for exploratory purposes in pain patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1013","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T10:36:41Z","timestamp":1487327801000},"page":"1098-1109","source":"Crossref","is-referenced-by-count":13,"title":["Histaminergic and non\u2010histaminergic elicited itch is attenuated in capsaicin\u2010evoked areas of allodynia and hyperalgesia: A healthy volunteer study"],"prefix":"10.1002","volume":"21","author":[{"given":"H.H.","family":"Andersen","sequence":"first","affiliation":[{"name":"Laboratory for Experimental Cutaneous Pain Research SMI<sup>\u00ae<\/sup> Department of Health Science and Technology Faculty of Medicine Aalborg University Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Elberling","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Copenhagen University Hospital Herlev\u2010Gentofte Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Cutaneous Pain Research SMI<sup>\u00ae<\/sup> Department of Health Science and Technology Faculty of Medicine Aalborg University Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"Hauberg","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Cutaneous Pain Research SMI<sup>\u00ae<\/sup> Department of Health Science and Technology Faculty of Medicine Aalborg University Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gazerani","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Cutaneous Pain Research SMI<sup>\u00ae<\/sup> Department of Health Science and Technology Faculty of Medicine Aalborg University Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Arendt\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Cutaneous Pain Research SMI<sup>\u00ae<\/sup> Department of Health Science and Technology Faculty of Medicine Aalborg University 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