{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:49:27Z","timestamp":1790675367294,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chronic Pain Research Group","award":["KTIA_NAP_13-2014-0022"],"award-info":[{"award-number":["KTIA_NAP_13-2014-0022"]}]},{"name":"Chronic Pain Research Group","award":["888819"],"award-info":[{"award-number":["888819"]}]},{"name":"GINOP","award":["2.3.2-15-2016-00050"],"award-info":[{"award-number":["2.3.2-15-2016-00050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical studies demonstrated peripheral nociceptor deficit in stress\u2010related chronic pain states, such as fibromyalgia. The interactions of stress and nociceptive systems have special relevance in chronic pain, but the underlying mechanisms including the role of specific nociceptor populations remain unknown. We investigated the role of capsaicin\u2010sensitive neurones in chronic stress\u2010related nociceptive changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Capsaicin\u2010sensitive neurones were desensitized by the capsaicin analogue resiniferatoxin (<jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>1 mice. The effects of desensitization on chronic restraint stress (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>)\u2010induced responses were analysed using behavioural tests, chronic neuronal activity assessment in the central nervous system with FosB immunohistochemistry and peripheral cytokine concentration measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic restraint stress induced mechanical and cold hypersensitivity and increased light preference in the light\u2013dark box test. Open\u2010field and tail suspension test activities were not altered. Adrenal weight increased, whereas thymus and body weights decreased in response to <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>. FosB immunopositivity increased in the insular cortex, dorsomedial hypothalamic and dorsal raphe nuclei, but not in the spinal cord dorsal horn after the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> did not affect the cytokine concentrations of hindpaw tissues. Surprisingly, <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> pretreatment augmented stress\u2010induced mechanical hyperalgesia, abolished light preference and selectively decreased the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>\u2010induced neuronal activation in the insular cortex. <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content> pretreatment alone increased the basal noxious heat threshold without influencing the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>\u2010evoked cold hyperalgesia and augmented neuronal activation in the somatosensory cortex and interleukin\u20101\u03b1 and <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content> production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic restraint stress induces hyperalgesia without major anxiety, depression\u2010like behaviour or peripheral inflammatory changes. Increased stress\u2010induced mechanical hypersensitivity in <jats:styled-content style=\"fixed-case\">RTX<\/jats:styled-content>\u2010pretreated mice is presumably mediated by central mechanisms including cortical plastic changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These are the first data demonstrating the complex interactions between capsaicin\u2010sensitive neurones and chronic stress and their impact on nociception. Capsaicin\u2010sensitive neurones are protective against stress\u2010induced mechanical hyperalgesia by influencing neuronal plasticity in the brain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1043","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T07:43:56Z","timestamp":1493192636000},"page":"1417-1431","source":"Crossref","is-referenced-by-count":47,"title":["Chronic stress\u2010induced mechanical hyperalgesia is controlled by capsaicin\u2010sensitive neurones in the mouse"],"prefix":"10.1002","volume":"21","author":[{"given":"B.","family":"Scheich","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vincze","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9.","family":"Sz\u0151ke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"},{"name":"MTA\u2010PTE NAP B Chronic Pain Research Group P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9.","family":"Borb\u00e9ly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Hunyady","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Szolcs\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy University of P\u00e9cs Medical School Hungary"},{"name":"J\u00e1nos Szent\u00e1gothai Research Centre Centre for Neuroscience University of P\u00e9cs Hungary"},{"name":"PharmInVivo Ltd. 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