{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:58:47Z","timestamp":1786366727452,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["P061007 CRC 06013"],"award-info":[{"award-number":["P061007 CRC 06013"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The administration of an equimolar mixture of nitrous oxide and oxygen (N2O) is recommended during painful procedures. However, the evaluation of its use during physiotherapy after surgery has not been reported, although pain may hamper physiotherapy efficiency. This study investigated whether the use of N2O improves the efficacy of post\u2010operative physiotherapy after multilevel surgery in patients with cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>It was a randomized 1:1, double\u2010blind, placebo\u2010controlled study. All patients had post\u2010operative physiotherapy starting the day after surgery. Patients received either N2O or placebo gas during the rehabilitation sessions. All patients had post\u2010operative pain management protocol, including pain medication as needed for acute pain. The primary objective was to reach angles of knee flexion of 110\u00b0 combined with hip extension of 10\u00b0, with the patient lying prone, within six or less physiotherapy sessions. Secondary evaluation criteria were the number of sessions required to reach the targeted angles, the session\u2010related pain intensity and the analgesics consumption for managing post\u2010operative pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients were enrolled. Targeted angles were achieved more often in the N2O group (23 of 32, 72%, vs. Placebo: 13\/ of 32, 41%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The administration of N2O during post\u2010operative physiotherapy can help to achieve more quickly an improved range of motion, and, although not significant in our study, to alleviate the need for pain medication. Further studies evaluating the administration of N2O in various settings are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>During this randomized placebo\u2010controlled double\u2010blind study, children receiving nitrous oxide and oxygen (N2O) achieved more often the targeted range of motion during physiotherapy sessions after multilevel surgery. Compared to placebo, nitrous oxide and oxygen (N2O) enabled a better management of acute pain related to physiotherapy procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1071","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T07:37:35Z","timestamp":1500536255000},"page":"1657-1667","source":"Crossref","is-referenced-by-count":6,"title":["Equimolar mixture of nitroux oxyde and oxygen during post\u2010operative physiotherapy in patients with cerebral palsy: A randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1002","volume":"21","author":[{"given":"A.","family":"Delafontaine","sequence":"first","affiliation":[{"name":"AP\u2010HP H\u00f4pital Robert Debr\u00e9 Service de Chirurgie Orthop\u00e9dique Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Presedo","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Robert Debr\u00e9 Service de Chirurgie Orthop\u00e9dique 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