{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:42:07Z","timestamp":1793497327117,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000323","name":"Pain Relief Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Fibromyalgia syndrome (\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      ) is a chronic pain disorder characterized by widespread pain, sleep disturbance, fatigue and cognitive\/affective symptoms. Functional imaging studies have revealed that\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      and other chronic pain syndromes can affect resting brain activity. This study utilized electroencephalographic (\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      ) recordings to investigate the relative power of ongoing oscillatory activity in the resting brain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 64\u2010channel\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      was recorded at rest in 19 female\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      patients and 18 healthy, age\u2010matched, control subjects. The Manual Tender Point Scale (\n                      <jats:styled-content style=\"fixed-case\">MTPS<\/jats:styled-content>\n                      ) examination was performed to quantify tonic pain and tenderness on the day of testing along with measures of mood, arousal and fatigue. Oscillations in delta, theta, alpha, beta and gamma frequency bands were analysed using Standardised Low\u2010Resolution Brain Electromagnetic Tomography to evaluate sources of spectral activity throughout the whole brain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      patients exhibited greater pain, tiredness and tension on the day of testing relative to healthy control participants and augmented theta activity in prefrontal and anterior cingulate cortices. No significant differences were seen in other frequency bands. Augmented frontal theta activity in\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      patients significantly correlated with measures of tenderness and mean tiredness scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings indicate that alterations to resting\u2010state oscillatory activity may relate to ongoing tonic pain and fatigue in\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      , and manifest in brain regions relevant for cognitive\u2010attentional aspects of pain processing and endogenous pain inhibition. Enhanced low\u2010frequency oscillations were previously seen in\n                      <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>\n                      and other chronic pain syndromes, and may relate to pathophysiological mechanisms for ongoing pain such as thalamocortical dysrhythmia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      Increased prefrontal theta activity may contribute to persistent pain in fibromyalgia or represent the outcome of prolonged symptoms. The findings point to the potential for therapeutic interventions aimed at normalizing neural oscillations, while further research utilizing quantitative analysis of resting\n                      <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>\n                      could benefit our understanding of fibromyalgia pathophysiology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1076","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T04:30:47Z","timestamp":1501475447000},"page":"49-57","source":"Crossref","is-referenced-by-count":104,"title":["Altered theta oscillations in resting\n                    <scp>EEG<\/scp>\n                    of fibromyalgia syndrome patients"],"prefix":"10.1002","volume":"22","author":[{"given":"N.","family":"Fallon","sequence":"first","affiliation":[{"name":"Department Psychological Sciences Institute of Psychology, Health, and Society, University of Liverpool 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