{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:45:38Z","timestamp":1771649138823,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuroimmune interactions play a vital role in many of the most common pain conditions, such as arthritis. There have been many attempts to derive clinically predictive information from an individual's inflammatory response in order to gauge subsequent pain perception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Here, we wanted to test whether this effort could be enhanced and complemented by the use of a model system which takes into account the function of not just circulating, but also tissue\u2010resident immune cells: ultraviolet B (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) irradiation of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted psychophysical and transcriptional analysis of hyperalgesia arising as a result of <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>\u2010induced inflammation in patients before total knee arthroplasty (<jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a023). Levels of acute postoperative pain were assessed and correlated with preoperative data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytokine and chemokine responses after <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation were found to be inversely correlated with the level of pain experienced after surgery (Spearman's \u03c1\u00a0=\u00a0\u22120.498).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It may be possible to use this simple model to study and predict the nature of neuro\u2010immune responses at more remote, clinically relevant sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>A simple model of <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> inflammation in the skin might predict the degree of a patient's neuro\u2010immune response and the extent of their postoperative pain after total knee arthroplasty.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1113","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T01:38:49Z","timestamp":1505439529000},"page":"170-180","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative ultraviolet B inflammation in skin: Modelling individual differences in acute postoperative pain and neuro\u2010immune interactions"],"prefix":"10.1002","volume":"22","author":[{"given":"T.H.","family":"Lunn","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Copenhagen University Hospital Hvidovre Denmark"},{"name":"The Lundbeck Centre for Fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Dawes","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford 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