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The mechanical and thermal hypersensitivity were assessed using the von Frey filament, radiant heat and acetone drop tests. Histopathological and apoptotic changes and the level of FGF<\/jats:styled-content>1, GFAP<\/jats:styled-content> and TNF<\/jats:styled-content>\u03b1 proteins were assessed in the lumbar portion (L4\u2013L6). Moreover, AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> were labelled with 99m<\/jats:sup>Tc \u2010HMPAO<\/jats:styled-content> and isolated organ counting were performed upon AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> administration.<\/jats:p><\/jats:sec>Results<\/jats:title>Administration of AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> attenuated the CCI<\/jats:styled-content>\u2010induced mechanical and thermal hypersensitivity. Spinal structural alterations and apoptosis were decreased in the AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> group. The injection of either phosphate\u2010buffered saline or normal NIH<\/jats:styled-content>3T3 fibroblasts could not attenuate the behavioural symptoms of neuropathic pain. Increased genetically engineered cells were counted in the injured sciatic nerve and the elevated levels of FGF<\/jats:styled-content>1 were detected in the spinal tissue. Stem cell therapy lead to decrement the level of the CCI<\/jats:styled-content>\u2010induced TNF<\/jats:styled-content>\u2010\u03b1 and GFAP<\/jats:styled-content> expression.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The intravenous administration of AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> could be considered as a potential remedy for the management of neuropathic pain.<\/jats:p><\/jats:sec>Significance<\/jats:title>AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> attenuated the CCI<\/jats:styled-content>\u2010induced mechanical and thermal hypersensitivity. Spinal structural alterations and apoptosis were significantly decreased in the AD<\/jats:styled-content>\u2010MSC<\/jats:styled-content>s FGF<\/jats:sup><\/jats:styled-content>1<\/jats:sup> group. 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