{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:18Z","timestamp":1786977738182,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>\n \n \n \n This updated systematic review aimed at evaluating the efficacy, acceptability and safety of cognitive behavioural therapies (\n CBT<\/jats:styled-content>\n s) in fibromyalgia syndrome (\n FMS<\/jats:styled-content>\n ). Clinicaltrials.gov, Cochrane Library,\n MEDLINE<\/jats:styled-content>\n , Psyc\n INFO<\/jats:styled-content>\n and\n SCOPUS<\/jats:styled-content>\n were searched from September 2013 to May 2017. Randomized controlled trials (\n RCT<\/jats:styled-content>\n s) comparing\n CBT<\/jats:styled-content>\n s with controls were analysed. Primary outcomes were \u226550% pain relief, \u226520% improvement of health\u2010related quality of life (\n HRQoL<\/jats:styled-content>\n ), negative mood, fatigue, disability, acceptability and safety at end of therapy and at 6\u00a0months follow\u2010up. Effects were summarized by a random effects model using risk differences (\n RD<\/jats:styled-content>\n ) or standardized mean differences (\n SMD<\/jats:styled-content>\n ) with 95% confidence intervals (\n CI<\/jats:styled-content>\n ). 29\n RCT<\/jats:styled-content>\n s with 2509 subjects were included.\n CBT<\/jats:styled-content>\n s were superior to controls (waiting list, attention control, treatment as usual, other active non\u2010pharmacological therapies) in pain relief of 50% or greater (\n RD<\/jats:styled-content>\n 0.05 [95%\n CI<\/jats:styled-content>\n 0.02\u20130.07] (high\u2010quality evidence), improvement of\n HRQoL<\/jats:styled-content>\n of 20% or greater (\n RD<\/jats:styled-content>\n 0.13 [95%\n CI<\/jats:styled-content>\n 0.00\u20130.26], (moderate quality evidence), and in reducing negative mood (\n SMD<\/jats:styled-content>\n \u22120.43 [95%\n CI<\/jats:styled-content>\n \u22120.62 to \u22120.24]) (high\u2010quality evidence), disability (\n SMD<\/jats:styled-content>\n \u22120.30 [95%\n CI<\/jats:styled-content>\n \u22120.52 to \u22120.08]) (high\u2010quality evidence) and fatigue (\n SMD<\/jats:styled-content>\n \u2013 0\u201327 [95%\n CI<\/jats:styled-content>\n \u22120.50 to \u22120.03]) (high\u2010quality evidence). There were no statistically significant differences between\n CBT<\/jats:styled-content>\n s and controls in acceptability and safety (high\u2010quality evidence). The update did not change the major findings of the previous review.\n CBT<\/jats:styled-content>\n s provided a clinically relevant benefit over control interventions in reducing some key symptoms of\n FMS<\/jats:styled-content>\n and disability at the end of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n \n This updated systematic review with meta\u2010analysis on cognitive behavioural therapies (\n CBT<\/jats:styled-content>\n s) including acceptance\u2010based\n CBT<\/jats:styled-content>\n s endorse the efficacy and tolerability of\n CBT<\/jats:styled-content>\n s in reducing key symptoms and disability in\n FMS<\/jats:styled-content>\n in the short\u2010 and long\u2010term if compared to waiting list, treatment as usual, attention controls and active non\u2010pharmacological therapies.\n CBT<\/jats:styled-content>\n s did not differ in efficacy except superiority for coping with pain and tolerability from recommended drug therapy (pregabalin and\/or duloxetine).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ejp.1121","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T05:42:44Z","timestamp":1507268564000},"page":"242-260","source":"Crossref","is-referenced-by-count":187,"title":["Efficacy, acceptability and safety of cognitive behavioural therapies in fibromyalgia syndrome \u2013 A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"22","author":[{"given":"K.","family":"Bernardy","sequence":"first","affiliation":[{"name":"Department of Pain Medicine BG University Hospital Bergmannsheil GmbH, Ruhr University Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Klose","sequence":"additional","affiliation":[{"name":"Department Internal and Integrative Medicine, Kliniken Essen\u2010Mitte, Faculty of Medicine University of Duisburg\u2010Essen 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