{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:29:31Z","timestamp":1769308171456,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral \u03b3\u2010aminobutyric acid (GABA<\/jats:styled-content>) receptors.<\/jats:p><\/jats:sec>Methods<\/jats:title>The effect of oral administration of test solutions (water, 0.5\u00a0mol\/L or 0.05\u00a0mol\/L GABA<\/jats:styled-content>, 1% lidocaine) was investigated for the amelioration of pain and sensitivity induced by application of capsaicin (1%, 2\u00a0min) to the tongue of thirty healthy male and female subjects in this four\u2010session, randomized, placebo\u2010controlled, double\u2010blinded, cross\u2010over study. Intra\u2010oral quantitative sensory testing was used to assess cold (CDT<\/jats:styled-content>), warm (WDT<\/jats:styled-content>) and mechanical (MDT<\/jats:styled-content>) detection thresholds as well as mechanical (MPT<\/jats:styled-content>) and heat (HPT<\/jats:styled-content>) pain thresholds. Capsaicin\u2010induced pain intensity was continuously rated on a 0\u201310 electronic visual analogue scale (VAS<\/jats:styled-content>). The area under the VAS<\/jats:styled-content> curve (VASAUC<\/jats:styled-content>) after rinsing was calculated for each solution.<\/jats:p><\/jats:sec>Results<\/jats:title>Capsaicin application on the tongue evoked burning pain with a peak of 4.8\/10, and significantly increased CDT<\/jats:styled-content> and MDT<\/jats:styled-content> while significantly decreasing WDT<\/jats:styled-content>, HPT<\/jats:styled-content>, and MPT<\/jats:styled-content>. The VASAUC<\/jats:styled-content> was significantly smaller after oral rinse with 0.05\u00a0mol\/L GABA<\/jats:styled-content>, 0.5\u00a0mol\/L GABA<\/jats:styled-content>, and 1% lidocaine than after oral rinse with water. Rinse with 0.5\u00a0mol\/L or 0.05\u00a0mol\/L GABA<\/jats:styled-content> were similarly effective in decreasing VASAUC<\/jats:styled-content>. Rinsing with either 1% lidocaine, 0.5\u00a0mol\/L or 0.05\u00a0mol\/L GABA<\/jats:styled-content> also significantly attenuated the effects of capsaicin on WDT<\/jats:styled-content> and HPT<\/jats:styled-content> in a treatment independent manner. There were no sex\u2010related differences in these effects of GABA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Capsaicin\u2010induced burning tongue pain and decreases in WDT<\/jats:styled-content> and HPT<\/jats:styled-content> can be ameliorated by rinsing the mouth with lidocaine and GABA<\/jats:styled-content> solutions.<\/jats:p><\/jats:sec>Significance<\/jats:title>Rinsing the mouth with an oral GABA<\/jats:styled-content> containing solution ameliorated burning pain and increased heat sensitivity produced by application of capsaicin to the tongue. This finding suggests that GABA<\/jats:styled-content> can act as a local analgesic agent in the oral cavity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1128","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T11:50:55Z","timestamp":1507722655000},"page":"393-401","source":"Crossref","is-referenced-by-count":5,"title":["\u03b3\u2010Aminobutyric acid (GABA) oral rinse reduces capsaicin\u2010induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects"],"prefix":"10.1002","volume":"22","author":[{"given":"Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain SMI Department of Health Science and Technology Faculty of Medicine Aalborg University Aalborg Denmark"},{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases Department of Oral Anatomy & Physiology School of Stomatology The Fourth Military Medical University Xi'An China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Somatosensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Arendt\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain SMI Department of Health Science and Technology Faculty of Medicine Aalborg University Aalborg Denmark"},{"name":"Center for Somatosensory\u2010Motor Interaction Department of Health Science and Technology Faculty of Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.E.","family":"Cairns","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain SMI Department of 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