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Nonetheless, there is only limited knowledge about factors leading to chronic intensive care\u2010related pain (<jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>). Thus, the primary objective was the identification of predictors of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>. Moreover, we aimed to assess the impact of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> on patients\u2019 health\u2010related quality of Life (<jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comprehensive information on patients\u2019 pain before <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission and present pain was collected longitudinally by means of the German Pain Questionnaire 6 and 12\u00a0months after <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> discharge (<jats:styled-content style=\"fixed-case\">ICU<jats:sub>DC<\/jats:sub><\/jats:styled-content>). In addition, a subsample of patients underwent Quantitative Sensory Testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>). We used Generalized Estimating Equations to identify predictors of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> with logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 204 patients (197\/159 at 6\/12\u00a0months after <jats:styled-content style=\"fixed-case\">ICU<jats:sub>DC<\/jats:sub><\/jats:styled-content>) were available for the analyses. In the multivariate models, moderate to severe average pain in the 4\u00a0weeks after <jats:styled-content style=\"fixed-case\">ICU<jats:sub>DC<\/jats:sub><\/jats:styled-content>, lower age, female sex, increased inflammation and chronic pain conditions and increased levels of anxiety before <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission were predictive for <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>. In addition, small fibre deficits and lower disease severity were associated with <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> subsample (81 patients, 77\/55 at 6\/12\u00a0months after <jats:styled-content style=\"fixed-case\">ICU<jats:sub>DC<\/jats:sub><\/jats:styled-content>). Patients with <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> reported significantly lower <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> than patients without <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic intensive care\u2010related pain is associated with specific decrements in <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>. Knowledge about the identified predictors is of clinical and scientific importance and might help to reduce the incidence of <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Chronic intensive care\u2010related pain is associated with specific decrements in health\u2010related quality of life. While most of the identified predictors for <jats:styled-content style=\"fixed-case\">CIRP<\/jats:styled-content> can only be considered as risk factors, especially adequate (post\u2010) acute pain management should be studied as preventive strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1129","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T02:46:34Z","timestamp":1509936394000},"page":"402-413","source":"Crossref","is-referenced-by-count":18,"title":["Chronic intensive care\u2010related pain: Exploratory analysis on predictors and influence on health\u2010related quality of life"],"prefix":"10.1002","volume":"22","author":[{"given":"P.","family":"Baumbach","sequence":"first","affiliation":[{"name":"Integrated Research and Treatment Center Center for Sepsis Control and Care (CSCC) Jena University Hospital Germany"},{"name":"Department of Anesthesiology and Intensive Care Medicine Jena University Hospital 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