{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:05:29Z","timestamp":1778634329998,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to provide a simple, descriptive health\u2010status profile for cancer patients with bone metastases, based on the EuroQol <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D, a tool commonly used to measure health utility scores, and to evaluate its association with the Brief Pain Inventory (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>), a legacy pain\u2010assessment tool. Although pain is one of five health\u2010status dimensions measured by the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D, our understanding of how pain relates to the other <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D dimensions is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We derived data from 5500 patients with bone metastases who completed the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D and <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>. Regression analyses examined how <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content> severity and interference scores correlated with <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D utility scores and how <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content> items associated with <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D items, for the entire sample and by disease\u2010type subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regardless of cancer site, the percentage of patients reporting moderate\/severe problems in each of the five <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D dimensions were pain\/discomfort, 78%; usual activities, 58%; mobility, 55%; anxiety\/depression, 57%; and self\u2010care, 26%. <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content> pain interference explained more of the variability in the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D utility scores than did pain severity (<jats:italic>R<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a041% vs. 34%). <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content> worst pain, average pain, pain now, interference with general activity, and interference with work significantly predicted <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D pain\/discomfort, with odds ratio estimates &lt;1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pain\/discomfort was the worst\u2010rated dimension of the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D in this population, but the relationship of this item to <jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content> pain severity was modest, suggesting that the single pain item of the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D may be of limited utility in studies for which pain is an endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Health\u2010status dimensions include more than pain. We examine the contribution of pain severity and pain\u2010related functional interference in determining the health status of cancer patients with bone metastases. The pain dimension from a health\u2010status measure may be an inadequate metric in clinical trials\/clinical practice when pain is an important outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1139","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T08:52:58Z","timestamp":1509353578000},"page":"565-571","source":"Crossref","is-referenced-by-count":5,"title":["The contribution of pain in determining the health status of cancer patients with bone metastases: A secondary analysis of data from three Phase <scp>III<\/scp> registration trials"],"prefix":"10.1002","volume":"22","author":[{"given":"T. R.","family":"Mendoza","sequence":"first","affiliation":[{"name":"Department of Symptom Research The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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