{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:24:52Z","timestamp":1781778292424,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["HEALTH\u2010F2\u20102013\u2010 602891"],"award-info":[{"award-number":["HEALTH\u2010F2\u20102013\u2010 602891"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2014\u2010SGR\u20101547"],"award-info":[{"award-number":["2014\u2010SGR\u20101547"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pregabalin is a first\u2010line agent for neuropathic pain treatment whose abuse liability remains controversial. Surprisingly, studies exploring the reinforcing properties of pregabalin in operant mouse models are missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the acquisition of operant pregabalin self\u2010administration in mice exposed to a partial sciatic nerve ligation (<jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content>) or a sham operation. After surgery, mice were trained in operant boxes to intravenously self\u2010administer pregabalin at 1.5 or 3\u00a0mg\/kg\/inf or saline during 10\u00a0days. Thermal and mechanical sensitivity were assessed before and after self\u2010medication, and depressive\u2010like behaviour was evaluated after discontinuation of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Partial sciatic nerve ligation and sham\u2010operated mice exposed to pregabalin at 3\u00a0mg\/kg\/inf showed higher active responding compared to mice exposed to saline. The differences in active responding were more robust in nerve\u2010injured than in sham\u2010operated mice. Self\u2010medication at either dose of pregabalin partially inhibited thermal hypersensitivity, whereas only self\u2010medication at 3\u00a0mg\/kg\/inf reduced mechanical sensitivity. Finally, a depressive\u2010like behaviour was revealed after saline treatment in nerve\u2010injured mice, and this emotional manifestation was abolished after pregabalin treatment at the high dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregabalin showed reinforcing effects both in <jats:styled-content style=\"fixed-case\">PSNL<\/jats:styled-content> and sham\u2010operated mice and attenuated the nociceptive and emotional manifestations of neuropathic pain in mice self\u2010administering this drug. Therefore, pregabalin self\u2010administration was related to neuropathic pain relief, but also to reinforcing properties related to psychotropic drug effects. This study reveals the improvement in nociceptive and emotional manifestations of neuropathic pain after operant pregabalin self\u2010medication in mice and suggests the reinforcing effects of this drug in an operant paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study shows that mice with a nerve injury self\u2010administer pregabalin at doses effective reducing nociceptive hypersensitivity and depressive\u2010like behaviour associated with the neuropathic pain model. Interestingly, mice without neuropathy also develop operant self\u2010administration behaviour, suggesting potential abuse liability of this first\u2010line drug for neuropathic pain treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1161","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T07:36:42Z","timestamp":1514360202000},"page":"763-773","source":"Crossref","is-referenced-by-count":15,"title":["Operant self\u2010administration of pregabalin in a mouse model of neuropathic pain"],"prefix":"10.1002","volume":"22","author":[{"given":"S.A.","family":"Bura","sequence":"first","affiliation":[{"name":"Laboratori de Neurofarmacologia Departament de Ci\u00e8ncies Experimentals i de la Salut Universitat Pompeu Fabra Parc de Recerca Biomedica de Barcelona (PRBB) Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Caba\u00f1ero","sequence":"additional","affiliation":[{"name":"Laboratori de Neurofarmacologia Departament 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