{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:11:29Z","timestamp":1777572689900,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SPUM 33CM30_140339"],"award-info":[{"award-number":["SPUM 33CM30_140339"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drugs are prescribed for chronic low back pain without knowing in advance whether a patient will respond to them or not. Quantitative sensory tests (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) can discriminate patients according to sensory phenotype, possibly reflecting underlying mechanisms of pain processing. <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> may therefore be a screening tool to identify potential responders to a certain drug. The aim of this study was to investigate whether <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> can predict analgesic effects of oxycodone, imipramine and clobazam in chronic low back pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oxycodone 15\u00a0mg (<jats:italic>n\u00a0<\/jats:italic>=\u00a050), imipramine 75\u00a0mg (<jats:italic>n\u00a0<\/jats:italic>=\u00a050) and clobazam 20\u00a0mg (<jats:italic>n\u00a0<\/jats:italic>=\u00a049) were compared to active placebo tolterodine 1\u00a0mg in a randomized, double\u2010blinded, crossover fashion. Electrical, pressure and thermal <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> were performed at baseline and after 1 and 2\u00a0h. Pain intensity was assessed on a 0\u201310 numeric rating scale every 30\u00a0min for up to 2\u00a0h. The ability of baseline <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> to predict pain reduction after 2\u00a0h was analysed using linear mixed models. Genetic variants of drug\u2010metabolizing enzymes and genes affecting pain sensitivity were examined as covariables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No predictor of analgesic effect was found for oxycodone and clobazam. Thermal <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> was associated with analgesic effect of imipramine: patients more sensitive to heat or cold were more likely to experience an effect of imipramine. Pharmacogenetic variants and pain\u2010related candidate genes were not associated with drug efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thermal <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> have the potential to predict imipramine effect in chronic low back pain. Oxycodone and clobazam effects could not be predicted by any of the selected <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content> or genetic variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Predicting drug efficacy in chronic low back pain remains difficult. There is some evidence that patients more sensitive to heat and cold pain respond better to imipramine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1183","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T03:08:54Z","timestamp":1516763334000},"page":"973-988","source":"Crossref","is-referenced-by-count":39,"title":["Predicting drug efficacy in chronic low back pain by quantitative sensory tests"],"prefix":"10.1002","volume":"22","author":[{"given":"J.","family":"Schliessbach","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Inselspital Bern University Hospital University of Bern  Switzerland"},{"name":"Institute of Anesthesiology University Hospital Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Siegenthaler","sequence":"additional","affiliation":[{"name":"Chronic Pain Management Lindenhof Hospital Lindenhof Group Bern 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