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Pain is frequently experienced in weight\u2010bearing joints, but is common in other areas of the body as well, suggesting other factors. Poor diet often contributes to obesity and can directly influence the immune system. We have shown that poor diet prolongs recovery from inflammatory injury. Therefore, our goal was to determine whether poor\u2010quality diet\u2010induced consequences could be prevented or reversed by an anti\u2010inflammatory diet (<jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Standard American Diet (<jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content>) was developed to investigate the effects of poor diet on pain. The <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> includes amounts of refined sugar, carbohydrates and fats that better model the typical American diet, as compared to high\u2010fat diets. We developed an <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content> to explore whether the effects of the <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> could reverse or whether the <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content> would enhance recovery prophylactically. The <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content> was developed using ingredients (epigallocatechin gallate, sulforaphane, resveratrol, curcumin and ginseng) with known anti\u2010inflammatory properties. Following 15\u00a0weeks of diet [<jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AID<\/jats:styled-content> or regular (<jats:styled-content style=\"fixed-case\">REG<\/jats:styled-content>)] exposure, male and female mice underwent inflammatory injury, at which point some animals had their diets switched for the remainder of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Animals who consumed the <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> showed longer recovery compared to the <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">REG<\/jats:styled-content>\u2010fed animals. Animals switched off the <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> had faster recovery times, with <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content>\u2010fed animals recovering as fast as <jats:styled-content style=\"fixed-case\">REG<\/jats:styled-content>\u2010fed animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Poor diet prolonged recovery from inflammatory injury. Substitution of <jats:styled-content style=\"fixed-case\">SAD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">AID<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">REG<\/jats:styled-content> promoted faster recovery. These findings suggest diet can be used as a non\u2010pharmacological intervention following injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Obesity may increase susceptibility to chronic pain often due to poor diet. Diet has potential to be used as treatment for pain. This study investigates the use of a novel translatable diet to act as a preventative (i.e. prior to surgery) or an intervention (i.e. following an injury).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1207","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T07:26:50Z","timestamp":1518506810000},"page":"1203-1213","source":"Crossref","is-referenced-by-count":35,"title":["Effects of a Standard American Diet and an anti\u2010inflammatory diet in male and female mice"],"prefix":"10.1002","volume":"22","author":[{"given":"S.K.","family":"Totsch","sequence":"first","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.Y.","family":"Meir","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Alabama at Birmingham AL 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