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Our recent studies revealed that the receptor for <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>1R, is expressed in mouse <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> sensory neurons, and its activation leads to flow\u2010activation and modulation of <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 channel function, resulting in peripheral heat and mechanical hypersensitivity. In order to verify the translatability of our findings in rodents to humans, we explored whether this signalling axis operates in primary human <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> sensory neurons. Analysis of gene expression data from recently reported <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> deep sequencing experiments performed on mouse and human <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content>s reveals that <jats:italic><jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>1R<\/jats:italic> is expressed in <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> and tibial nerve. Furthermore, exposure of cultured human <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> neurons to <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP leads to slow\u2010sustained activation of <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 and modulation of capsaicin\u2010induced channel activation. Both activation and modulation of <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 by <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP were dependent on <jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content> activity. Our findings suggest that functional <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>rP\/<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>1R\u2010<jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>1 signalling exists in human <jats:styled-content style=\"fixed-case\">DRG<\/jats:styled-content> neurons, which could contribute to local nociceptor excitation in the vicinity of metastatic bone tumor microenvironment.<\/jats:p>","DOI":"10.1002\/ejp.1251","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T16:29:57Z","timestamp":1527179397000},"page":"1685-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Parathyroid hormone\u2010related peptide activates and modulates <scp>TRPV<\/scp>1 channel in human <scp>DRG<\/scp> 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