{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:18:03Z","timestamp":1792171083107,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiofrequency ablation (<jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>) of the splanchnic nerves has been reported as a predictable and safe technique for abdominal pain management. We compare between <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> and chemical neurolysis of bilateral thoracic splanchnic nerves in the management of refractory cancer pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted on 60 patients aged \u226518\u00a0years who suffered from abdominal pain (visceral pain, <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> \u22654) due to upper abdominal cancers. Participants were randomized into two groups. Group I (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>): 30 participants received a bilateral splanchnic nerve block at T10 and T11 levels using <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content>. Group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (alcohol): 30 participants received a bilateral splanchnic nerve block at T11 using alcohol. Pain relief was assessed using <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> (0\u201310) and total daily oral opioid consumption (primary outcome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reductions of <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> and global perceived effect satisfaction scores (<jats:styled-content style=\"fixed-case\">GPES<\/jats:styled-content>) were observed in both groups compared to baseline levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); Group I had the largest reduction. <jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content> consumption and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> scores improved significantly in both groups (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Oral opioid consumption started to reduce at the end of the first post\u2010interventional week for Group I, 0.00 (0\u201345\u00a0mg), and at the\u00a0end of the second post\u2010interventional week for Group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, 20.00 (0\u2013135\u00a0mg). No major complications were recorded in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simultaneous bilateral pain block of splanchnic nerves at the levels of T10 and T11 using <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> is more effective than using alcohol at a single level of T11 in cancer patients presenting with upper abdominal pain. The <jats:styled-content style=\"fixed-case\">RFA<\/jats:styled-content> intervention acted faster, provided longer duration analgesia, worked in a higher proportion of patients and had a better safety profile than the alcohol intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Radiofrequency ablation of the splanchnic nerves is safe and effective for relieving upper abdominal cancer pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1274","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T16:34:37Z","timestamp":1530808477000},"page":"1782-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comparison between radiofrequency ablation and chemical neurolysis of thoracic splanchnic nerves for the management of abdominal cancer pain, randomized trial"],"prefix":"10.1002","volume":"22","author":[{"given":"S.A.","family":"Amr","sequence":"first","affiliation":[{"name":"Department of Anesthesia, ICU and Pain Relief South Egypt Cancer Institute Assiut University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Reyad","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, and Pain Relief National Cancer Institute Cairo University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, ICU and Pain Relief South Egypt Cancer Institute Assiut University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, ICU and Pain Relief South Egypt Cancer Institute Assiut University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, ICU and Pain Relief South Egypt Cancer Institute Assiut University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.H.","family":"Alieldin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Cancer Epidemiology National Cancer Institute Cairo University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, ICU and Pain Relief South Egypt Cancer Institute Assiut University Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm056"},{"key":"e_1_2_6_3_1","first-page":"259","volume-title":"Relief of 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