{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:10:47Z","timestamp":1694848247163},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Anaesthesiology and Intensive Care Medicine of the University Hospital Cologn"},{"name":"BMBF-funded consortium","award":["0315449D","0316177A"],"award-info":[{"award-number":["0315449D","0316177A"]}]},{"name":"\u2018Modelling of peripheral pain switches (MoPS)\u2019","award":["0315449D"],"award-info":[{"award-number":["0315449D"]}]},{"name":"\u2018Nociceptor Pain Model","award":["0316177A"],"award-info":[{"award-number":["0316177A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Previously, we found in cultures of primary neurons and in animals that sensitized primary neurons can be desensitized by treatment with e.g. beta\u2010adrenergic receptor agonists. We now tested whether also in human sensitization such as UVB\u2010radiation induced sunburn\u2010like hyperalgesia can be reduced by intradermal injection of the beta\u2010adrenergic receptor agonist terbutaline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our prospective randomized study, 17 participants received an individual UVB dose to cause a defined local sunburn\u2010like erythema at four locations, two on each forearm. Twenty\u2010four hours later, the sensitized four areas were injected intradermally with terbutaline pH 4.3, terbutaline pH 7.0, saline pH 4.3 or saline pH 7.0, respectively. Pain thresholds were examined before and after induction of UVB\u2010sensitization, and 15, 30 and 60\u00a0min after injection of the respective solution. Mechanical pain thresholds of the skin and of deeper tissues were determined by pinprick and pressure algometer measurements, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UVB\u2010irradiation decreased mechanical pain thresholds for pinprick and pressure algometer measurements demonstrating a successful sunburn\u2010like sensitization. Intradermal injection of terbutaline pH 7.0 into the sensitized skin reduced the sensitization for all measured timepoints as determined by pinprick measurements. Pinprick measurements of sensitization were not reduced by injection of terbutaline pH 4.3, saline solution pH 7.0 or saline solution pH 4.3. Also, sensitization of deeper tissue nociceptors were not altered by any of the injections as measured with the pressure algometer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar to our cellular observations, also in humans beta\u2010adrenergic agonists such as terbutaline can reduce the sensitization of primary neurons in the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We previously showed in model systems that beta\u2010adrenergic stimulation can not only sensitize but also desensitize nociceptors. Our study shows that also in humans beta\u2010adrenergic agonists desensitize if injected into UVB\u2010sensitized skin. This indicates an analgesic activity of adrenergic agonists in addition to their vasoconstrictory function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1286","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T06:49:10Z","timestamp":1531118950000},"page":"72-80","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The beta\u2010adrenergic receptor agonist, terbutaline, reduces UVB\u2010induced mechanical sensitization in humans"],"prefix":"10.1002","volume":"23","author":[{"given":"J.","family":"Loeser","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine University Clinic of Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Blunk","sequence":"additional","affiliation":[{"name":"Department of Pain Therapy Hospital zum Heiligen Geist GmbH Kempen 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