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As interoceptive sensitivity and underlying neural mechanisms remain incompletely understood, this functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) study assessed behavioural and neural responses to visceral stimuli in primary dysmenorrhoea (<jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content> (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>19) without psychological comorbidity and healthy women (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>20) were compared with respect to visceral sensory and pain thresholds, and to neural responses to individually calibrated mildly painful and painful rectal distensions implemented during scanning. Trial\u2010by\u2010trial ratings of perceived intensity were accomplished with visual analogue scales (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although women with dysmenorrhoea reported significantly higher chronic pain intensity and pain interference with daily life activities (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01, assessed with the West Haven\u2010Yale Multidimensional Pain Inventory), there were no differences between groups in visceral sensitivity and mean trial\u2010by\u2010trial <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> ratings were virtually identical. Analysis of neural responses revealed activation in brain regions previously shown to be involved in the processing of visceral stimuli with differences between painful and mildly painful stimulation, but no group differences were found even when using a liberal statistical threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dysmenorrhoea patients show unaltered perceptual and neural responses to experimental interoceptive stimuli. Despite limited sample size, these negative results argue against a generalized sensitization towards interoceptive stimuli in patients without psychological comorbidities. Future studies should clarify the role of psychosocial factors in central sensitization using more pain region\u2010specific models in larger and clinically more heterogeneous samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Despite higher chronic pain and pain interference with daily life activities, women with primary dysmenorrhoea do not differ from healthy women with respect to visceral sensitivity or neural processing of aversive interoceptive stimuli induced by rectal distensions. Generalized sensitization may be present only in subgroups with pronounced psychosocial or psychiatric disturbances.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1302","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T07:20:27Z","timestamp":1533972027000},"page":"272-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Behavioural and neural responses to aversive visceral stimuli in women with primary dysmenorrhoea"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-9130","authenticated-orcid":false,"given":"Bettina","family":"B\u00f6ttcher","sequence":"first","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke R.","family":"Gizewski","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical University Innsbruck Innsbruck Austria"},{"name":"Neuroimaging Research Core Facility Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Siedentopf","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical University Innsbruck Innsbruck Austria"},{"name":"Neuroimaging Research Core Facility Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Steiger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Medical University Innsbruck Innsbruck Austria"},{"name":"Neuroimaging Research Core Facility Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Verius","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Riedl","sequence":"additional","affiliation":[{"name":"University Clinic of Medical Psychology Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Ischebeck","sequence":"additional","affiliation":[{"name":"Institute of Psychology Karl\u2010Franzens\u2010University Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schmid","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Wildt","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Elsenbruch","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Hospital Essen University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(83)90156-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00844930"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12403"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02657.2000"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200205000-00007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/0167482X.2018.1470619"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2014.01.108"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet421"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000099"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.03.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.030"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu205"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.12.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/786830"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der156"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.827"},{"key":"e_1_2_8_19_1","first-page":"489","article-title":"Primary dysmenorrhea","volume":"60","author":"Coco A. 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