{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:53Z","timestamp":1786977593653,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We analysed outcome domains and pain outcome measures in randomized controlled trials of interventions for postoperative pain management in children and adolescents and compared them to the core outcome set recommended by the Pediatric Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Systematic literature search was conducted in\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">CDSR<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">DARE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>\n                      and Psyc\n                      <jats:styled-content style=\"fixed-case\">INFO<\/jats:styled-content>\n                      up to 31 January 2017. One author extracted data and second verified the extraction. Outcome domains and pain outcome measures were analysed and compared with the Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      core outcome set.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 337 trials. Median number of reported outcomes was five (range 1\u201311) for the included trials and two (range 0\u20136) for Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      . The most commonly analysed Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      outcome domains were pain intensity (93%) and \u201csymptoms and adverse events\u201d (83%). The remaining four Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      outcomes were present in under 30% of included randomized controlled trials. Proportion of Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      outcome domains did not change after the Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      was published in 2008. Of the 312 trials that reported pain intensity, 303 (97%) also specified pain assessment tools, in which the most common was the visual analogue scale (24%) followed by the Children's Hospital of Eastern Ontario Pain Scale (18%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Analysed trials about interventions for pediatric postoperative pain insufficiently used the recommended core outcome set for acute pain in children. Relevance of the Ped\n                      <jats:styled-content style=\"fixed-case\">IMMPACT<\/jats:styled-content>\n                      core outcome set, as well as the reasons behind its limited uptake, need to be further evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Recommended core outcomes have been insufficiently used in randomized controlled trials about postoperative pain in children, which hinders comparability of studies and makes synthesis of evidence difficult.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1313","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T10:21:47Z","timestamp":1536056507000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcome domains and pain outcome measures in randomized controlled trials of interventions for postoperative pain in children and adolescents"],"prefix":"10.1002","volume":"23","author":[{"given":"Krste","family":"Boric","sequence":"first","affiliation":[{"name":"Department of Traumatology and Orthopaedics University Hospital Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Jelicic Kadic","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Boric","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery University Hospital Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Zarandi\u2010Nowroozi","sequence":"additional","affiliation":[{"name":"Laboratory for Pain Research School of Medicine University of Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Jakus","sequence":"additional","affiliation":[{"name":"Laboratory for Pain Research School of Medicine University of Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Cavar","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Center Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svjetlana","family":"Dosenovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care University Hospital Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milka","family":"Jeric","sequence":"additional","affiliation":[{"name":"Department of Dermatovenerology General Hospital Zadar Zadar Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijan","family":"Batinic","sequence":"additional","affiliation":[{"name":"Laboratory for Pain Research School of Medicine University of Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Vukovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care University Hospital Split Split Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Puljak","sequence":"additional","affiliation":[{"name":"Laboratory for Pain Research School of Medicine University of Split Split Croatia"},{"name":"Department for Development, Research and Health Technology Assessment Agency for Medicinal Products and Medical Devices Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/17.1.95"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.03.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0079"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13203"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnx255"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03209-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-0738-6"},{"key":"e_1_2_6_9_1","unstructured":"COMET. 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