{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:34:28Z","timestamp":1790739268423,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In complex regional pain syndrome (CRPS), altered perception of the affected hand and neglect\u2010like symptoms of the affected body side are common features. In this study, we presented tactile stimuli to the affected hands in CRPS patients and matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The participants\u2019 task was to point at the perceived positions of the stimuli using a tracking device. The spatial coordinates of the perceived positions were analysed for accuracy and consistency. We also presented patterns consisting of two stimuli at distinct positions with a delay of 100\u00a0ms. These patterns are known to induce spatiotemporal integration (\u201csensory saltation\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRPS patients were less accurate and less consistent in the spatial perception of tactile stimuli on their hands. Furthermore, they showed increased spatiotemporal integration, although these effects were smaller than expected. These deficiencies were related to the clinically assessed intensity of recurrent pain episodes. Surprisingly, the intensity of clinically assessed ongoing pain was associated with increased precision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In line with earlier reports, our findings indicate that the representation of the affected hands in CRPS patients is less accurate than in healthy people, probably reflecting reorganization in somatosensory cortices. The exact relationships between these findings and other aspects of CRPS remain to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>CRPS patients performed poorly in localizing positions on their affected hands via pointing and exhibited increased spatiotemporal integration. The presented method may prove useful in diagnostics as well as psychophysical and neurofunctional research on CRPS and other chronic pain disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1321","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T05:24:50Z","timestamp":1538803490000},"page":"472-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Altered tactile localization and spatiotemporal integration in complex regional pain syndrome patients"],"prefix":"10.1002","volume":"23","author":[{"given":"J\u00f6rg","family":"Trojan","sequence":"first","affiliation":[{"name":"Department of Psychology University of Koblenz\u2010Landau  Landau Germany"},{"name":"Department of Cognitive und Clinical Neuroscience Medical Faculty Mannheim Central Institute of Mental Health Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Speck","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Kleinb\u00f6hl","sequence":"additional","affiliation":[{"name":"Department of Cognitive und Clinical Neuroscience Medical Faculty Mannheim Central Institute of Mental Health Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus","family":"Benrath","sequence":"additional","affiliation":[{"name":"Center of Pain Therapy Clinic of Anaesthesia and Intensive Care University Medical Center Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herta","family":"Flor","sequence":"additional","affiliation":[{"name":"Department of Cognitive und Clinical Neuroscience Medical Faculty Mannheim Central Institute of Mental Health Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Maih\u00f6fner","sequence":"additional","affiliation":[{"name":"Department of Neurology F\u00fcrth General Hospital  F\u00fcrth Germany"},{"name":"Department of Physiology and Pathophysiology University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.975"},{"key":"e_1_2_7_3_1","volume-title":"Morphometric tools for landmark data: Geometry and biology","author":"Bookstein F. 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