{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:27Z","timestamp":1792782267694,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Academic Health Sciences Centres of Ontario"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The study aims were to model acute pain intensity and opioid consumption trajectories up to 72\u00a0hr after open hepatic resection, identify predictors of trajectory membership and examine the association between trajectory memberships and 6\u2010month pain and psychological outcomes. This is a long\u2010term analysis of a published randomized controlled trial on the impact of medial open transversus abdominis plane catheters on post\u2010operative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 152 patients (89 males; mean age 63.0 [range: 54\u201372]) completed questionnaires on pain and related characteristics pre\u2010operatively and 6\u00a0months post\u2010operatively. Total opioid use was recorded several times over a 72\u2010hr period while self\u2010reported pain intensity scores were collected multiple times until hospital discharge. Analyses were carried out using growth mixture modelling, logistic regression and general linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both pain intensity and opioid consumption showed that a four\u2010trajectory model best fits the data. Patients in the lowest opioid consumption trajectory were more likely to be classified in the constant mild pain intensity trajectory. Age and baseline levels of anxiety significantly predicted opioid trajectory membership while baseline depressive symptoms significantly predicted pain intensity trajectory membership. Patients in the two highest opioid consumption trajectories reported significantly higher levels of pain catastrophizing at 6\u00a0months compared to patients in the other 3 trajectories (all\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High consumption of opioids after surgery is associated with higher levels of pain catastrophizing 6\u00a0months later. Identification of patients within these trajectories may lead to the development of early interventions targeted to high risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Differences in initial levels of opioid consumption and rates of change in opioid consumption shortly after surgery can help predict long\u2010term psychological responses to pain. Identifying key characteristics associated with initial opioid consumption can lead to the development of cost\u2010effective early interventions targeted to high risk individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1324","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T03:19:51Z","timestamp":1539055191000},"page":"503-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["In\u2010hospital opioid consumption, but not pain intensity scores, predicts 6\u2010month levels of pain catastrophizing following hepatic resection: A trajectory analysis"],"prefix":"10.1002","volume":"23","author":[{"given":"M. Gabrielle","family":"Pag\u00e9","sequence":"first","affiliation":[{"name":"Centre de recherche du Centre hospitalier de l\u2019 Universit\u00e9 de Montr\u00e9al (CRCHUM)  Montreal Qu\u00e9bec Canada"},{"name":"Department of anesthesiology and pain medicine Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Karanicolas","sequence":"additional","affiliation":[{"name":"Department of Surgery Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"},{"name":"Department of Health Policy, Management, and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Surgery University Health Network University of Toronto  Toronto Ontario Canada"},{"name":"Division of Hepatobiliary and Pancreas Surgery Mayo Clinic \u2013 Rochester  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgery University Health Network University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McHardy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima S. J.","family":"Ladak","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management University Health Network University of Toronto  Toronto Ontario Canada"},{"name":"Lawrence S. Bloomberg Faculty of Nursing University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Ayach","sequence":"additional","affiliation":[{"name":"Pain Research Unit Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Pain Research Unit Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coimbatore","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Pain Research Unit Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management University Health Network University of Toronto  Toronto Ontario Canada"},{"name":"Pain Research Unit Toronto General Hospital University Health Network  Toronto Ontario Canada"},{"name":"Department of psychology Faculty of Arts York University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Surgery Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"},{"name":"Department of Health Policy, Management, and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hallet","sequence":"additional","affiliation":[{"name":"Department of Surgery Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Surgery Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"},{"name":"Department of Health Policy, Management, and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Greig","sequence":"additional","affiliation":[{"name":"Department of Surgery Sunnybrook Health Sciences Centre University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hance","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Pain Management University Health Network University of Toronto  Toronto Ontario Canada"},{"name":"Pain Research Unit Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"277","article-title":"Information measures and model selection","volume":"44","author":"Akaike A.","year":"1983","journal-title":"International Statistical Institute"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00385.x"},{"key":"e_1_2_9_4_1","first-page":"27","volume-title":"Advances in latent variable mixture models","author":"Asparouhov T.","year":"2008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2012.09.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-3660-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/204946371100500306"},{"key":"e_1_2_9_9_1","first-page":"21","article-title":"Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review","volume":"8","author":"Burns L. 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