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Nerve lesions are known to produce sudomotor dysfunctions but also patients suffering from complex regional pain syndrome, CRPS1\u2014a condition without a nerve lesion\u2014present with sweating disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using proton nuclear magnetic resonance of sweat water, we quantified sweat output of mice suffering from a nerve lesion or a bone fracture without nerve lesion and correlated their sweating with behavioural paw hypersensitivity accessed in von Frey testings, water applications and weight\u2010bearing measured with an incapacitance metre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lesioned animals sweat less and are hypersensitive compared to healthy controls, as expected. Fractured animals on the injured side sweat less acutely after the injury but more in the chronic phase. They are hypersensitive acutely as well as chronically after the fracture. These findings resemble human bone trauma patients in the acute phase and CRPS patients in the chronic phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sweating disorders are present both in neuropathic animals and in those with a bone fracture without nerve lesions, and autonomic dysfunctions might be considered as an important component in the aetiology of neuropathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Sweat output changes in mice after bone trauma, potentially indicative of posttraumatic processes leading to CRPS in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1352","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T17:42:01Z","timestamp":1545673321000},"page":"835-842","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sweating disorders in mice with and without nerve lesions"],"prefix":"10.1002","volume":"23","author":[{"given":"Charlotte","family":"Guhl","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie Unimedizin Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Birklein","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie Unimedizin Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie Unimedizin Mainz Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90040-N"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.10.035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2012.02.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00309-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02267817"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000154"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817724"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1147"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2016.08.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33565-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01827433"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199208053"},{"key":"e_1_2_8_15_1","first-page":"1945","article-title":"Up\u2010regulation of cutaneous alpha1 \u2010adrenoceptors in complex regional pain syndrome type I","volume":"15","author":"Finch P. 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