{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:50:02Z","timestamp":1791870602311,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DE017018"],"award-info":[{"award-number":["U01DE017018"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple risk factors predict temporomandibular disorders (TMD) onset, but temporal changes in risk factors and their contribution to risk of TMD have not been evaluated. The study aims were to (a) describe changes occurring in premorbid TMD risk factors when re\u2010measured at TMD onset and 6\u00a0months later, and (b) determine if measures of change improve accuracy in predicting TMD incidence compared to premorbid measures alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this observational prospective cohort study at four university research clinics, 3,258 community\u2010based, 18\u2010 to 44\u2010year\u2010olds without TMD were enrolled. During the 3\u2010year median follow\u2010up, 260 incident cases of first\u2010onset TMD were identified, and 196 TMD\u2010free subjects were selected as matched controls. Six\u2010months later, 147 of 260 incident cases (56.6%) were re\u2010examined revealing 72 (49%) with \u2018persistent TMD\u2019 and 75 (51%) whose condition had resolved (\u2018transient TMD\u2019). Virtually all (126) of the 127 re\u2010examined controls remained without TMD. Questionnaires and clinical measurements evaluated risk factors from clinical, health, psychological and behavioural and neurosensory domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most risk factors across all four domains increased with TMD onset, remained elevated in the persistent group and declined in the transient group (i.e., significant ANOVA interactions,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Accuracy in predicting first\u2010onset TMD, quantified as area under the receiver operating characteristic curve was 0.71 (95% CL 0.68, 0.73) using only premorbid measures of risk factors, which increased to 0.91 (95% CL 0.89, 0.94) after addition of change measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TMD pain onset and persistence appear to be determined by enduring characteristics of the person as well as mutually interactive with temporally evolving variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>TMD is known to be a complex disorder, in which onset and persistence are associated with disease\u2010related variables in multiple domains, including environmental exposure, clinical, psychological, health status, and pain processing variables. Using a more dynamic approach in order to capture change across time, many aspects of those domains were found to worsen prior to the reporting of pain, with bidirectional influences between domains and pain emergence likely. TMD onset appears to represent the cumulative effect of multiple system dysregulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1472","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T10:50:02Z","timestamp":1566039002000},"page":"145-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Premorbid and concurrent predictors of TMD onset and persistence"],"prefix":"10.1002","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-9734","authenticated-orcid":false,"given":"Richard","family":"Ohrbach","sequence":"first","affiliation":[{"name":"Department of Oral Diagnostic Sciences University at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Slade","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"Center for Pain Research and Innovation University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bair","sequence":"additional","affiliation":[{"name":"Center for Pain Research and Innovation University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Biostatistics University of North Carolina Chapel Hill North Carolina"},{"name":"Department of Endodontics University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuvan","family":"Rathnayaka","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luda","family":"Diatchenko","sequence":"additional","affiliation":[{"name":"Alan Edwards Centre for Research on Pain McGill University Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, and Brotman Facial Pain Clinic University of Maryland School of Dentistry Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Maixner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Center for Translational Pain Medicine Duke University Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger B.","family":"Fillingim","sequence":"additional","affiliation":[{"name":"Pain Research and Intervention Center of Excellence Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.09.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000127692.23278.a9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.06.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.09.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.12.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.09.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197403000-00014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00123-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.04.015"},{"key":"e_1_2_8_13_1","first-page":"203","volume-title":"Epidemiology of pain","author":"Drangsholt M.","year":"1999"},{"issue":"4","key":"e_1_2_8_14_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique","volume":"6","author":"Dworkin S. 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