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However, few studies have addressed the efficacy of positive affect interventions in chronic pain populations and examined which patients can benefit more from them. The aim of the present study was to identify mediators and moderators of the best possible self intervention (BPS) in fibromyalgia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from a previous randomized controlled trial that examined changes in pain interference, depression, self\u2010efficacy and quality of life after the BPS intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mediation analyses showed that depression mediated changes in pain interference. Positive and negative affect were significant mediators of the change in depression and quality of life. No significant mediators of the change in self\u2010efficacy were found. Baseline levels of quality of life, emotion regulation strategies of negative and positive affect, and rumination moderated the effects of the intervention on depressive symptomatology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In fibromyalgia patients, the effects of the BPS on the outcomes seem to be more related to changes in affect than to changes in future expectations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study presents evidence about who can benefit from an intervention designed to augment positive affect and promote positive functioning in FMS patients and how these changes occur. It extends previous findings on patient characteristics associated with the response to pain management interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1481","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:04:20Z","timestamp":1567703060000},"page":"248-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["How and for whom does a positive affect intervention work in fibromyalgia: An analysis of mediators and moderators"],"prefix":"10.1002","volume":"24","author":[{"given":"Guadalupe","family":"Molinari","sequence":"first","affiliation":[{"name":"CIBER of Physiopathology of Obesity and Nutrition CIBERObn Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Miragall","sequence":"additional","affiliation":[{"name":"CIBER of Physiopathology of Obesity and Nutrition CIBERObn Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Personality, Evaluation and Psychological Treatment University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Enrique","sequence":"additional","affiliation":[{"name":"Trinity College School of Psychology Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Botella","sequence":"additional","affiliation":[{"name":"CIBER of Physiopathology of Obesity and Nutrition CIBERObn Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Psicolog\u00eda B\u00e1sica Universitat Jaume I Cl\u00ednica y Psicobiolog\u00eda Castell\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Ba\u00f1os","sequence":"additional","affiliation":[{"name":"CIBER of Physiopathology of Obesity and Nutrition CIBERObn Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Personality, Evaluation and Psychological Treatment University of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena","family":"Garc\u00eda\u2010Palacios","sequence":"additional","affiliation":[{"name":"CIBER of Physiopathology of Obesity and Nutrition CIBERObn Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Psicolog\u00eda B\u00e1sica Universitat Jaume I Cl\u00ednica y Psicobiolog\u00eda Castell\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17439760.2014.927906"},{"key":"e_1_2_7_3_1","volume-title":"Manual for the Beck Depression Inventory\u2010II","author":"Beck A. 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