{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:55:42Z","timestamp":1772006142469,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of peripheral neuropathy development and chronic pain is strongly associated with the arrival of senescence. The gradual physiological decline that begins after the mature stage produces myelin dysregulation and pathological changes in peripheral nervous system, attributed to reduction in myelin proteins expression and thinner myelin sheath. Moreover in elder subjects, when nerve damage occurs, the regenerative processes are seriously compromised and neuropathic pain (NeP) is maintained. We previously demonstrated that caloric restriction (CR) in adult (4\u00a0months) nerve\u2010lesioned mice was able to facilitate remyelination and axons regeneration, to have anti\u2010inflammatory action and to prevent NeP chronification. Here, we show CR therapeutic potential on nerve injury\u2010induced neuropathy in mice at the beginning of the senescence (12\u00a0months). Long lasting decrease in hypersensitvity induced by peripheral nerve lesion and powerful reduction in proinflammatory circulating agents have been observed. Moreover, our results evidence that CR is able to counteract the ageing\u2010related delay in axonal regeneration, enhancing Schwann cells proliferation and accelerating recovery processes. Differently from adults, it does not affect fibres myelination. In light of a continuous growth in elderly population and correlated health problems, including metabolic disorders, the prevalence of neuropathy is enhancing, generating a significant public cost and social concern. In this context energy depletion by dietary restriction can be a therapeutic option in NeP.<\/jats:p>","DOI":"10.1002\/ejp.1493","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T19:59:28Z","timestamp":1571083168000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of caloric restriction on peripheral nerve injury\u2010induced neuropathic pain during ageing in mice"],"prefix":"10.1002","volume":"24","author":[{"given":"Federica","family":"De Angelis","sequence":"first","affiliation":[{"name":"IRCCS \u2013 S. Lucia Foundation Rome Italy"},{"name":"CNR \u2013 Institute of Cell Biology and Neurobiology Monterotondo scalo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Vacca","sequence":"additional","affiliation":[{"name":"IRCCS \u2013 S. Lucia Foundation Rome Italy"},{"name":"CNR \u2013 Institute of Cell Biology and Neurobiology Monterotondo scalo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaminia","family":"Pavone","sequence":"additional","affiliation":[{"name":"CNR \u2013 Institute of Cell Biology and Neurobiology Monterotondo scalo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-4796","authenticated-orcid":false,"given":"Sara","family":"Marinelli","sequence":"additional","affiliation":[{"name":"CNR \u2013 Institute of Cell Biology and Neurobiology Monterotondo scalo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2014.09.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.10.006"},{"key":"e_1_2_6_4_1","first-page":"409\u2013413.Review","article-title":"Peripheral neuropathies and aging","volume":"16","author":"Brisset M.","year":"2018","journal-title":"G\u00e9riatrie Et Psychologie Neuropsychiatrie Du Vieillissement"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5048616"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19540563.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208596"},{"key":"e_1_2_6_8_1","first-page":"173\u2013206. 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