{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:47:03Z","timestamp":1791362823326,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread pain and a variety of non\u2010pain symptoms. Central sensitivity phenomena are found consistently in FMS. Additionally, several researchers proclaimed that a subgroup of FMS patients may present with unrecognized peripheral small fibre neuropathy (SFN). Laser\u2010evoked brain potentials (LEP) are considered as a reliable method for the functional assessment of the thermo\u2010nociceptive system, including the evaluation of SFN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this retrospective study was to estimate the prevalence of thermo\u2010nociceptive system dysfunction based on LEPs in FMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>LEP recordings of 92 FMS patients and 39 age and gender\u2010matched healthy controls were selected from a database collected between 2003 and 2012 with standardized settings for laser stimulation and EEG recording. The N1, N2 and P2 LEP components were identified and characterized by peak latency and amplitude.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the FMS patients showed signs of loss of function of the nociceptive responses evoked by A \u03b4\u2010nociceptor activation, compared to healthy controls. 6.5% of the FMS patients had N2\u2010P2 peak\u2010to\u2010peak amplitudes above the upper limit of the 99%\u2010confidence interval. N2\u2010P2 peak\u2010to\u2010peak amplitudes were negatively correlated with age, without age\u2010related differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The characteristic signs of a damaged thermo\u2010nociceptive system as revealed by LEPs were absent in this large cohort of FMS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The present research does not support the hypothesis that small fibre neuropathy is a significant contributor to the pathophysiology of FMS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1501","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T11:35:26Z","timestamp":1572521726000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Fibromyalgia syndrome\u2014A laser\u2010evoked potentials study unsupportive of small nerve fibre involvement"],"prefix":"10.1002","volume":"24","author":[{"given":"Dominique C. 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