{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:05:13Z","timestamp":1792649113135,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The dorsal root (DRG) and trigeminal (TG) ganglia contain cell bodies of sensory neurons of spinal and trigeminal systems, respectively. They are homologs of each other; however, differences in how the two systems respond to injury exist. Trigeminal nerve injuries rarely result in chronic neuropathic pain (NP). To date, no genes involved in the differential response to nerve injury between the two systems have been identified. We examined transcriptional changes involved in the development of trigeminal and spinal NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Trigeminal and spinal mononueropathies were induced by chronic constriction injury to the infraorbital or sciatic nerve. Expression levels of 84 genes in the TG and DRG at 4, 8 and 21\u00a0days post\u2010injury were measured using real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found time\u2010dependent and ganglion\u2010specific transcriptional regulation that may contribute to the development of corresponding neuropathies. Among genes significantly regulated in both ganglia <jats:italic>Cnr2, Grm5, Htr1a, Il10, Oprd1, Pdyn, Prok2<\/jats:italic> and <jats:italic>Tacr1<\/jats:italic> were up\u2010regulated in the TG but down\u2010regulated in the DRG at 4\u00a0days post\u2010injury; at 21\u00a0days post\u2010injury, <jats:italic>Adora1, Cd200, Comt, Maob, Mapk3, P2<\/jats:italic><jats:italic>rx4, Ptger1, Tnf<\/jats:italic> and <jats:italic>Slc6a2<\/jats:italic> were significantly up\u2010regulated in the TG but down\u2010regulated in the DRG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that spinal and trigeminal neuropathies due to trauma are differentially regulated. Subtle but important differences between the two ganglia may affect NP development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We present distinct transcriptional alterations in the TG and DRG that may contribute to differences observed in the corresponding mononeuropathies. Since the trigeminal system seems more resistant to developing NP following trauma our findings lay ground for future research to detect genes and pathways that may act in a protective or facilitatory manner. These may be novel and important therapeutic targets.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1546","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T13:03:30Z","timestamp":1582722210000},"page":"967-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Differential gene expression changes in the dorsal root versus trigeminal ganglia following peripheral nerve injury in rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Olga A.","family":"Korczeniewska","sequence":"first","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannina","family":"Katzmann Rider","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Gajra","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Narra","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishnavi","family":"Ramavajla","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Juan","family":"Chang","sequence":"additional","affiliation":[{"name":"Office of Advance Research Computing Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Center for Pain Medicine Research New Jersey Medical School Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Soteropoulos","sequence":"additional","affiliation":[{"name":"The Genomics Center New Jersey Medical School Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Husain","sequence":"additional","affiliation":[{"name":"The Genomics Center New Jersey Medical School Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junad","family":"Khan","sequence":"additional","affiliation":[{"name":"Eastman Institute of Oral Health University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Eliav","sequence":"additional","affiliation":[{"name":"Eastman Institute of Oral Health University of Rochester Medical Center Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Benoliel","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Sciences Rutgers School of Dental Medicine Rutgers, The State University of New Jersey Newark NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2010.03.021"},{"key":"e_1_2_8_3_1","unstructured":"Arikawa E. 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