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Since then a multitude of patients with caspr2 antibodies presenting with different neurological symptoms have been reported. Here, we describe three patients with caspr2 antibodies with different types of pain\/no pain in combination with peripheral neuropathy. The first patient, a 33\u2010year\u2010old woman, presented with erythromelalgia\u2010like pain and autonomic symptoms; the second patient, a 58\u2010year\u2010old man, with paresthesia and pain while walking together with signs of peripheral motor neuron hyperexcitability in combination with optic neuritis, and the third patient, a 74\u2010year\u2010old man, without any pain but with polyneuropathy and encephalopathy. These cases illustrate the spectrum of symptoms in anti\u2010caspr2 diseases. The pain in such cases can be treated causally.<\/jats:p>","DOI":"10.1002\/ejp.1572","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T05:39:17Z","timestamp":1586669957000},"page":"1411-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Heterogeneous presentation of caspr2 antibody\u2010associated peripheral neuropathy \u2013 A case series"],"prefix":"10.1002","volume":"24","author":[{"given":"Erik","family":"Ellwardt","sequence":"first","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology University Medical Center of the Johannes\u2010Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Geber","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology University Medical Center of the Johannes\u2010Gutenberg University Mainz Mainz Germany"},{"name":"DRK Schmerz\u2010Zentrum Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Lotz","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine University Medical Center of the Johannes\u2010Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Birklein","sequence":"additional","affiliation":[{"name":"Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology University Medical Center of the Johannes\u2010Gutenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1963.03860050075006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000087"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000753"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13180"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315720"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10364"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02969.x"},{"issue":"806","key":"e_1_2_9_10_1","first-page":"e10","article-title":"Immune or genetic\u2010mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability","volume":"97","author":"Dawes J. 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