{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:29:47Z","timestamp":1793665787640,"version":"4.5.1"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001063","name":"Raine Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001797","name":"Curtin University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Aim<\/jats:title>\n                    <jats:p>This study aimed to establish the somatosensory profile of patients with lumbar radiculopathy at pre\u2010and post\u2010microdiscectomy and to explore any association between pre\u2010surgical quantitative sensory test (QST) parameters and post\u2010surgical clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A standardized QST protocol was performed in 53 patients (mean age 38\u00a0\u00b1\u00a011\u00a0years, 26 females) with unilateral L5\/S1 radiculopathy in the main pain area (MPA), affected dermatome and contralateral mirror sites and in age\u2010 and gender\u2010,and body site\u2010matched healthy controls. Repeat measures at 3\u00a0months included QST, the Oswestry Disability Index (ODI) and numerous other clinical measures; at 12\u00a0months, only clinical measures were repeated. A change &lt;30% on the ODI was defined as \u2018no clinically meaningful improvement\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients showed a significant loss of function in their symptomatic leg both in the dermatome (thermal, mechanical, vibration detection\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.002), and MPA (thermal, mechanical, vibration detection, mechanical pain threshold, mechanical pain sensitivity\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.041) and increased cold sensitivity in the MPA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Pre\u2010surgical altered QST parameters improved significantly post\u2010surgery in the dermatome (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.018) in the symptomatic leg and in the MPA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.010), except for thermal detection thresholds and cold sensitivity. Clinical outcomes improved at 3 and 12\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Seven patients demonstrated &lt;30% change on the ODI at 12\u00a0months. Baseline loss of function in mechanical detection in the MPA was associated with &lt;30% change on the ODI at 12\u00a0months (OR 2.63, 95% CI 1.09\u20136.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microdiscectomy resulted in improvements in affected somatosensory parameters and clinical outcomes. Pre\u2010surgical mechanical detection thresholds may be predictive of clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study documented quantitative sensory testing (QST) profiles in patients with lumbar radiculopathy in their main pain area (MPA) and dermatome pre\u2010 and post\u2010microdiscectomy and explored associations between QST parameters and clinical outcome. Lumbar radiculopathy was associated with loss of function in modalities mediated by large and small sensory fibres. Microdiscectomy resulted in significant improvements in loss of function and clinical outcomes in 85% of our cohort. Pre\u2010surgical mechanical detection thresholds in the MPA may be predictive of clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1586","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T02:01:32Z","timestamp":1588903292000},"page":"1377-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association of quantitative sensory testing parameters with clinical outcome in patients with lumbar radiculopathy undergoing microdiscectomy"],"prefix":"10.1002","volume":"24","author":[{"given":"Brigitte","family":"Tampin","sequence":"first","affiliation":[{"name":"Department of Physiotherapy Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Neurosurgical Service of Western Australia Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"School of Physiotherapy and Exercise Science Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Slater","sequence":"additional","affiliation":[{"name":"School of Physiotherapy and Exercise Science Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"School of Physiotherapy and Exercise Science Curtin University Perth Western Australia Australia"},{"name":"Department of Research Sir Charles Gairdner Hospital Perth Western Australia Australia"},{"name":"Institute for Health Research The University of Notre Dame Australia Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R. 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