{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:55:46Z","timestamp":1775130946083,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laparoscopic surgeries are associated with less postoperative pain and adverse events compared to open procedures. But, it still reduces the quality of life in children. Transversus abdominis plane (TAP) block is used to reduce pain. We hypothesized that dexmedetomidine or clonidine could improve the analgesic profile of levobupivacaine to the same extent during TAP block in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety children were randomly allocated in a randomized double\u2010blind trial to receive bilateral TAP block with levobupivacaine plus normal saline (group B, <jats:italic>n<\/jats:italic>\u00a0=\u00a030), or dexmedetomidine (group D, <jats:italic>n<\/jats:italic>\u00a0=\u00a030) or clonidine (group C, <jats:italic>n<\/jats:italic>\u00a0=\u00a030). Primary outcome was the modified Children's Hospital of Eastern Ontario Pain Scale score. Secondary outcomes included time to initial analgesic request, number of analgesic claims, total analgesic consumption, parents' satisfaction, sedation score and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children of group D showed reduced pain scores compared to other groups. They represented the longest period of analgesia (565.00\u00a0\u00b1\u00a071.5\u00a0min) with <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, and fewer patients required two doses of analgesia during the first postoperative day. The cumulative amount of backup analgesia was significantly different between these groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026). Higher parents\u2019 satisfaction scores were recorded in groups D and C compared to group B. Sedation among the study groups revealed significant differences (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035), but no severe complications were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding dexmedetomidine to levobupivacaine can extend the time of analgesia and reduce the use of postoperative backup analgesics with minimal sedation effects when used in TAP block in paediatrics undergoing laparoscopic orchiopexy. Clonidine can be used as an alternative adjuvant to local anaesthetics with good postoperative analgesic profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Clonidine can alternate dexmedetomidine during TAP block with local anesthetics for pediatrics laparoscopies. Both can lead to better postoperative analgesic profiles. Clonidine may be preferred, especially in our developing regions, because of its easy availability and lower cost than that of dexmedetomidine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1689","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:12:16Z","timestamp":1604160736000},"page":"497-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound\u2010guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double\u2010blind study"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-7339","authenticated-orcid":false,"given":"Mohamed F.","family":"Mostafa","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragaa","family":"Herdan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_433_19"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.101213"},{"key":"e_1_2_8_4_1","article-title":"Effects of adding dexmedetomidine to local infiltration of bupivacaine on postoperative pain in pediatric herniorrhaphy: A randomized clinical trial. 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