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Our objective was to investigate differences in and modulation of intracortical responses from SI and ACC in response to different intensities of peripheral presumed noxious and non\u2010noxious stimuli in the acute time frame of a peripheral nerve injury in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied non\u2010noxious and noxious electrical stimulation pulses through a cuff electrode placed around the sciatic nerve and measured the cortical responses (six electrodes in each cortical area) before and after the spared nerve injury model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the peak response correlated with the stimulation intensity and that SI and ACC differed in both amplitude and latency of cortical response. The cortical response to both noxious and non\u2010noxious stimulation showed a trend towards faster processing of non\u2010noxious stimuli in ACC and increased cortical processing of non\u2010noxious stimuli in SI after SNI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found different responses in SI and ACC to different intensity electrical stimulations based on two features and changes in these features following peripheral nerve injury. We believe that these features may be able to assist to track cortical changes during the chronification of pain in future animal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study showed distinct cortical processing of noxious and non\u2010noxious peripheral stimuli in SI and ACC. The processing latency in ACC and accumulated spiking activity in SI appeared to be modulated by peripheral nerve injury, which elaborated on the function of these two areas in the processing of nociception.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1697","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T20:47:14Z","timestamp":1604954834000},"page":"612-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of SI and ACC response to noxious and non\u2010noxious electrical stimuli after the spared nerve injury model of neuropathic pain"],"prefix":"10.1002","volume":"25","author":[{"given":"Lea","family":"T\u00f8ttrup","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP) Department of Health Science and Technology Aalborg University Aalborg 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