{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T15:54:12Z","timestamp":1773590052609,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stress activates several neural pathways that inhibit pain sensation. Nucleus accumbens (NAc), as an important component of the mesolimbic dopaminergic system, has a major role in pain modulation and is differentially affected by stress. Based on the nature of stressors, the direction of this effect is controversial. We previously showed that forced swim stress\u2010induced analgesia through activation of NAc dopamine receptors. In this study, we aimed to examine the role of dopamine receptors within the NAc in restraint stress (RS)\u2010induced analgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats weighing 230\u2013250\u00a0g were unilaterally implanted with a cannula into the NAc. D1\u2010like dopamine receptor antagonist, SCH\u201023390 (0.25, 1 and 4\u00a0\u00b5g\/0.5\u00a0\u00b5L saline), or D2\u2010like dopamine receptor antagonist, Sulpiride (0.25, 1 and 4\u00b5g\/0.5\u00b5l DMSO), were microinjected into NAc in two separate super groups 5\u00a0min prior to exposure to RS. Their control groups just received intra\u2010accumbal saline or DMSO (0.5\u00a0\u00b5l) respectively. The formalin test was performed after animals were subjected to RS using Plexiglas tubes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results demonstrated that RS produces analgesia in both phases of the formalin test. Intra\u2010NAc injection of SCH\u201023390 equally reduced RS\u2010induced analgesia in both early and late phases of the formalin test, while Sulpiride reduced RS\u2010induced analgesia just at the late phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the dopaminergic system might act as a potential endogenous pain control system in stress conditions. However, the lack of evaluation of the role of the dopaminergic system in RS\u2010induced antinociception in acute pain conditions is considered as a limitation for this study. In addition, a comprehensive evaluation of this endogenous pain control system in animal and clinical studies will guide future efforts for developing more effective medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Restraint stress (RS) induces the antinociceptive behaviors in both phases of formalin test. Blockade of intra\u2010accumbal dopamine receptors impresses the antinociception induced by RS. Blockade of D1\u2010like dopamine receptor equally reduced RS\u2010induced analgesia in both early and late phases of the formalin test. Blockade of D2\u2010like dopamine receptor reduced RS\u2010induced analgesia just at the late phase.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1716","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T17:21:45Z","timestamp":1608484905000},"page":"862-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intra\u2010accumbal dopaminergic system modulates the restraint stress\u2010induced antinociceptive behaviours in persistent inflammatory pain"],"prefix":"10.1002","volume":"25","author":[{"given":"Golnaz","family":"Faramarzi","sequence":"first","affiliation":[{"name":"Neuroscience Research Center School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Department of Physiology Faculty of Veterinary Medicine University of Tehran Tehran 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