{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:04:08Z","timestamp":1774915448291,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We assessed whether COVID\u201019 is associated with de novo pain and de novo chronic pain (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This controlled cross\u2010sectional study was based on phone interviews of patients discharged from hospital after COVID\u201019 compared to the control group composed of individuals hospitalized during the same period due to non\u2010COVID\u201019 causes. Patients were classified as having previous CP based on the ICD\u201011\/IASP criteria, de novo <jats:italic>pain<\/jats:italic> (i.e. any new type of pain, irrespective of the pain status before hospital stay), and de novo CP (i.e. persistent or recurring de novo pain, lasting more than 3\u00a0months) after COVID\u201019. We assessed pain prevalence and its characteristics, including headache profile, pain location, intensity, interference, and its relationship with fatigue, and persistent anosmia. Forty\u2010six COVID\u201019 and 73 control patients were included. Both groups had similar sociodemographic characteristics and past medical history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Length of in\u2010hospital\u2010stay and ICU admission rates were significantly higher amongst COVID\u201019 survivours, while mechanical ventilation requirement was similar between groups. Pre\u2010hospitalisation pain was lower in COVID\u201019 compared to control group (10.9% vs. 42.5%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). However, the COVID\u201019 group had a significantly higher prevalence of de novo pain (65.2% vs. 11.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), as well as more de novo headache (39.1%) compared to controls (2.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). New\u2010onset CP was 19.6% in COVID\u201019 patients and 1.4% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) in controls. These differences remained significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) even after analysing exclusively (COVID: <jats:italic>n<\/jats:italic>\u00a0=\u00a040; controls: <jats:italic>n<\/jats:italic>\u00a0=\u00a034) patients who did not report previous pain before the hospital stay. No statistically significant differences were found for mean new\u2010onset pain intensity and interference with daily activities between both groups. COVID\u201019 pain was more frequently located in the head\/neck and lower limbs (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). New\u2010onset fatigue was more common in COVID\u201019 survivours necessitating inpatient hospital care (66.8%) compared to controls (2.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). COVID\u201019 patients who reported anosmia had more new\u2010onset pain (83.3%) compared to those who did not (48.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 was associated with a significantly higher prevalence of de novo CP, chronic daily headache, and new\u2010onset pain in general, which was associated with persistent anosmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>There exists de novo pain in a substantial number of COVID\u201019 survivours, and some develop chronic pain. New\u2010onset pain after the infection was more common in patients who reported anosmia after hospital discharge.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1755","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T08:02:40Z","timestamp":1614067360000},"page":"1342-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Prevalence and characteristics of new\u2010onset pain in COVID\u201019 survivours, a controlled study"],"prefix":"10.1002","volume":"25","author":[{"given":"Felipe Henriques Carvalho","family":"Soares","sequence":"first","affiliation":[{"name":"Pain Center Department of Neurology University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Taricani","family":"Kubota","sequence":"additional","affiliation":[{"name":"Pain Center Department of Neurology University of S\u00e3o Paulo S\u00e3o Paulo 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