{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:29:53Z","timestamp":1771338593680,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unlike motor symptoms, the effects of deep brain stimulation (DBS) on non\u2010motor symptoms associated with dystonia remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The objective of this study was to assess the effects of DBS on evoked experimental pain and cutaneous sensory thresholds in a crossover, double\u2010blind on\/off study and compare these results with those of healthy volunteers (HV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients with idiopathic dystonia (39.9\u00a0\u00b1\u00a013\u00a0years old, <jats:italic>n<\/jats:italic>\u00a0=\u00a014 generalized) with DBS of the globus pallidus internus underwent a battery of quantitative sensory testing and assessment using a pain top\u2010down modulation system (conditioned pain modulation, CPM). Results for the more and less dystonic body regions were compared in on and off stimulation. The patients' results were compared to age\u2010 and sex\u2010matched HV. Descending pain modulation CPM responses in dystonic patients (on\u2010DBS, 11.8\u00a0\u00b1\u00a040.7; off\u2010DBS, 1.8\u00a0\u00b1\u00a022.1) was abnormally low (defective) compared to HV (\u221215.6\u00a0\u00b1\u00a023.5, respectively <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042). Cold pain threshold and cold hyperalgesia were 54.8% and 95.7% higher in dystonic patients compared to HV. On\u2010DBS CPM correlated with higher Burke\u2010Fahn\u2010Marsden disability score (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.598; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014). While sensory and pain thresholds were not affected by DBS on\/off condition, pain modulation was abnormal in dystonic patients and tended to be aggravated by DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The analgesic effects after DBS do not seem to depend on short\u2010duration changes in cutaneous sensory thresholds in dystonic patients and may be related to changes in the central processing of nociceptive inputs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1757","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T16:52:40Z","timestamp":1616172760000},"page":"1355-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abnormal sensory thresholds of dystonic patients are not affected by deep brain stimulation"],"prefix":"10.1002","volume":"25","author":[{"given":"Clarice","family":"Listik","sequence":"first","affiliation":[{"name":"Movement Disorders Center Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Gisbert","family":"Cury","sequence":"additional","affiliation":[{"name":"Movement Disorders Center Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valquiria Aparecida","family":"da Silva","sequence":"additional","affiliation":[{"name":"Pain Center Neurosurgery Division Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Carvalho Barbosa","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Movement Disorders Center Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Listik","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naira","family":"Link","sequence":"additional","affiliation":[{"name":"Pain Center Neurosurgery Division Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Galhardoni","sequence":"additional","affiliation":[{"name":"Pain Center Neurosurgery Division Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"},{"name":"Federal University of ABC S\u00e3o Bernardo do Campo SP Brazil"},{"name":"School of Medicine Santo Andr\u00e9 SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egberto Reis","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Movement Disorders Center Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Pain Center Neurosurgery Division Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ciampi de Andrade","sequence":"additional","affiliation":[{"name":"Movement Disorders Center Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"},{"name":"Pain Center Neurosurgery Division Department of Neurology School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo SP Brazil"},{"name":"Pain Center Instituto do Cancer do Estado de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2018.06.078"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.105"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00314-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89101995000500004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.1.73"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25255"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww102"},{"key":"e_1_2_11_10_1","first-page":"151","volume-title":"SF\u201012 health related quality of life in COPD patients: A population\u2010based study in S\u00e3o Paulo\u2010SP","author":"Camelier A. 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