{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:42:33Z","timestamp":1790185353108,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary dysmenorrhoea (PDM) is known to alter brain static functional activity. This study aimed to explore the dynamic topological properties (DTP) of dynamic brain functional network in women with PDM in the pain\u2010free phase and their performance in distinguishing PDM in the pain\u2010free phase from healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five women with PDM and 38 healthy women without PDM were included. A dynamic brain functional network was constructed using the slide\u2010window approach. The stability (TP\u2010Stab) and variability (TP\u2010Var) of the DTP of the dynamic functional network were computed using the graph\u2010theory method. A support vector machine (SVM) was used to evaluate the performance of DTP in identifying PDM in the pain\u2010free phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, women with PDM had not only lower TP\u2010Stab in global DTP, which included cluster clustering coefficient (<jats:italic>C<jats:sub>p<\/jats:sub><\/jats:italic>), characteristic path length (<jats:italic>L<jats:sub>p<\/jats:sub><\/jats:italic>), global efficiency (<jats:italic>E<jats:sub>g<\/jats:sub><\/jats:italic>) and local efficiency (<jats:italic>E<jats:sub>loc<\/jats:sub><\/jats:italic>), but also lower TP\u2010Stab and higher TP\u2010Var in nodal DTP (nodal efficiency, <jats:italic>E<jats:sub>nod<\/jats:sub><\/jats:italic>), mainly in the prefrontal cortex, anterior cingulate cortex, parahippocampal regions and insula. The TP\u2010Stab and TP\u2010Var were significantly correlated with psychological variables, that is positive emotions, sense of control and meaningful existence. SVM analysis showed that the DTP could identify PDM in the pain\u2010free phase from healthy controls with an accuracy of 79.31%, sensitivity of 82.61% and specificity of 76%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with PDM in the pain\u2010free phase have altered global DTP and nodal DTP, mainly involving pain\u2010related neurocircuits. The highly variable brain network is helpful for identifying PDM in the pain\u2010free phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study shows that women with primary dysmenorrhoea (PDM) have decreased stability of dynamic network topological properties (DTP) and increased DTP variability in the pain\u2010free phase. The altered DTP can be used to identify PDM in the pain\u2010free phase. These findings demonstrate the presence of unstable characteristics in the whole network and disrupted pain\u2010related neurocircuits, which might be used as potential classifiers for PDM in the pain\u2010free phase. This study improves our knowledge of the brain mechanisms underlying PDM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1808","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T04:01:35Z","timestamp":1621396895000},"page":"1912-1924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic network topological properties for classifying primary dysmenorrhoea in the pain\u2010free phase"],"prefix":"10.1002","volume":"25","author":[{"given":"Xiaoyan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"School of Psychology South China Normal University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Precise Genome Engineering Center School of Life Sciences Guangzhou University Guangzhou China"},{"name":"School of Education Jinggangshan University Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuwei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology First People's Hospital of Kashgar Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Precise Genome Engineering Center School of Life Sciences Guangzhou University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208933109"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3874-05.2006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400087101"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.04.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15534510.2012.664326"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.68"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0362-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-040510-143934"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2018.2875456"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.01.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001428"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.11.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9646-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.05.001"},{"issue":"6","key":"e_1_2_9_18_1","first-page":"1058","article-title":"Altered dynamic of EEG oscillations in fibromyalgia patients at rest","volume":"17","author":"Gonzalez\u2010Roldan A. 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