{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:48:46Z","timestamp":1774532926775,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["2519ATS001"],"award-info":[{"award-number":["2519ATS001"]}],"id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Strong opioids can have unintended effects. Clinical studies of strong opioids mainly report physical side effects, psychiatric or opioid use disorders. To date, too little attention has been paid to the psychological effects of opioids to treat patients with chronic noncancer pain (CNCP). This study aims to identify and measure (i) the nature and frequency of physical and psychological effects and (ii) the degree of physician counseling of patients with CNCP taking strong opioids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within a cross\u2010sectional survey\u2014conducted as part of a randomised controlled online intervention trial (ERONA [<jats:bold>E<\/jats:bold>xperiencing the <jats:bold>r<\/jats:bold>isk of overusing <jats:bold>o<\/jats:bold>pioids among patients with chronic <jats:bold>n<\/jats:bold>on\u2010cancer pain in <jats:bold>a<\/jats:bold>mbulatory care])\u2014300 German CNCP patients were surveyed via patient\u2010reported outcome measures regarding on both the side effects from their use of strong opioids as well as their counselling experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the patients\u2019 reported effects, the psychological outcomes of the opioids in CNCP were: feeling relaxed (84%), fatigue (76%), dizziness (57%), listlessness (37%), difficulty with mental activities (23%), dulled emotions (17%) and poor memory (17%). Ninety\u2010two per cent of the patients reported having received information about opioid effects, and 46% had discussed cessation of the opioid medication with their physicians before commencing the prescription.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to the well\u2010known physical side effects, patients with CNCP taking strong opioids experience significant psychological effects. In view of these effects, discontinuation of opioid therapy should be discussed early to ensure their benefits do not outweigh their harm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>In this study, patients with non\u2010cancer pain notice that opioids they have taken do not only cause physical side effects but also may have an impact on their psyche and their emotions and, thus, may also affect quality of life substantially.<\/jats:p><jats:p><jats:bold>Clinical trial number:<\/jats:bold> DRKS00020358.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1868","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T19:52:44Z","timestamp":1633031564000},"page":"417-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patients\u2019 self\u2010reported physical and psychological effects of opioid use in chronic noncancer pain\u2014A retrospective cross\u2010sectional analysis"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9393-8537","authenticated-orcid":false,"given":"Erika","family":"Schulte","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-0495","authenticated-orcid":false,"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-8799","authenticated-orcid":false,"given":"Claudia","family":"Denke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg J.","family":"Meerpohl","sequence":"additional","affiliation":[{"name":"Institute for Evidence in Medicine (for Cochrane Germany Foundation) Medical Center &amp; Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Cochrane Germany Cochrane Germany Foundation  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-1835","authenticated-orcid":false,"given":"Norbert","family":"Donner\u2010Banzhoff","sequence":"additional","affiliation":[{"name":"Department of Primary Care Phillips University Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3265-8889","authenticated-orcid":false,"given":"Frank","family":"Petzke","sequence":"additional","affiliation":[{"name":"Pain Clinic Department of Anesthesiology Universit\u00e4tsmedizin G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-9556","authenticated-orcid":false,"given":"Ralph","family":"Hertwig","sequence":"additional","affiliation":[{"name":"Center for Adaptive Rationality Max\u2010Planck\u2010Institut f\u00fcr Bildungsforschung  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK) Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-2673","authenticated-orcid":false,"given":"Odette","family":"Wegwarth","sequence":"additional","affiliation":[{"name":"Center for Adaptive Rationality Max\u2010Planck\u2010Institut f\u00fcr Bildungsforschung  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12741"},{"key":"e_1_2_7_4_1","volume-title":"AWMF\u2010Register Nr. 145\/003. 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