{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:59Z","timestamp":1786977719582,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pain plays a central role in endometriosis. The complex relationship among pain characteristics, comorbid pain disorders and daily life represents a challenge for medical support. This multicentre cross\u2010sectional case\u2013control study analysed the association between endometriosis\u2010related chronic pain and functions of daily life in 510 women with endometriosis, 265 (52%) who experienced chronic pain, either from endometriosis alone (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a0134, 26.3%) or in association with additional pain disorders (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a0131, 25.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Self\u2010administered questionnaires from the Brief Pain Inventory and the Pain Disability Index were used to investigate associations between pain characteristics (frequency, duration, intensity) and daily life. Also, associations between different endometriosis characteristics (rASRM stage, presence of adhesions, localisation of lesions) and pain were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic pain is negatively associated with almost all (12\/14) aspects of daily life investigated, including standing, walking, sitting, defaecation, sleep, sports activities, family and domestic responsibilities, sexuality, social functioning, professional life, mood, and joy of life. Altogether, 33.7% of women with chronic pain reported moderate and 27.5% severe limitations. Comorbid pain disorders resulted in significantly more limitations. The length of pain episodes showed a particularly important influence, especially for family\/domestic responsibilities (OR 22.94,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001), professional life (OR 16.56,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) and social functioning (OR 41.03,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data confirm that despite treatment, about 50% of women experience pain. Pain was associated with at least moderate negative effects on almost all areas of daily life; additional pain comorbidities increased limitations. Improving pain management is essential for improving quality of life in women with endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The study provides an accurate overview of the impact of endometriosis\u2010associated pain on daily life. This is important because pain plays a central role in women living with endometriosis, and despite modern therapies, many women continue to suffer from chronic pain. The detailed analysis of its impact with a comprehensive survey of all aspects of daily life in a very large study population is unique. We expect an improved understanding of consequences of pain to significantly advance medical support in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.1926","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T22:27:57Z","timestamp":1645309677000},"page":"1021-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Living with endometriosis: Comorbid pain disorders, characteristics of pain and relevance for daily life"],"prefix":"10.1002","volume":"26","author":[{"given":"Janine","family":"Leuenberger","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Sabrina","family":"Kohl Schwartz","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Geraedts","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Haeberlin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Eberhard","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Cantonal Hospital Schaffhausen  Schaffhausen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"von Orellie","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Triemli Hospital  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Imesch","sequence":"additional","affiliation":[{"name":"Department of Gynecology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Leeners","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"46","article-title":"Minimal to mild endometriosis: 4 treatment options","volume":"16","author":"Adamson D.","year":"2004","journal-title":"OBG Management"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.11.049"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.8.1744"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.7.1895"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2431-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.29.2112"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001362"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.04.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.10.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5301\/JE.2011.8525"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1601307"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00487-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.10.030"},{"key":"e_1_2_9_20_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland C. 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