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The most common garlic products are garlic powder (dried garlic), steam distilled garlic oils, garlic oil macerate and aged garlic extract. These commercial products contain organosulphur compounds (OSCs) that have been extensively evaluated in preclinical models and some clinical assays to treat different diseases against pain. In this review, we describe the importance of some bioactive compounds found in garlic and their role in treating pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>A systematic search of the literature in Dimensions, PubMed, Scopus, and Web of Science was performed. Terms and preselected keywords relating to garlic, its derivatives and organusulphure compounds in acute, chronic and neuropathic pain, were used to perform a systematic literature search. Two independent reviewers screened the papers for inclusion and assessed the methodological quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Discussion<\/jats:title><jats:p>The antinociceptive activity of garlic and its OSC is related to its antioxidant and anti\u2010inflammatory properties, which may be explained by the ability to block the synthesis of PGs, pro\u2010inflammatory cytokines and interferon\u2010\u03b3, by the reduction COX\u20102 activity and increasing the levels of anti\u2010inflammatory cytokines. Besides, garlic extract is an activator of TRPA1 and TRPV1, where the principal responsible for this activation are OSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relationship between these pathways allows a better understanding how garlic and its derivates could be carrying out its pharmacological action over the management of acute and chronic pain and provide a base by further investigations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Antinociceptive effect of garlic and its OSCs has been extensively evaluated in preclinical models and clinical assays to treat different diseases, contributing to the modulation of inflammation as an essential factor in reducing pain. The current review emphasizes the potential therapeutic effect of garlic and its derivatives in treatment of pain and related mechanisms of action. Moreover, it provides information about the potential clinical use in patients with painful conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1935","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T16:29:51Z","timestamp":1646843391000},"page":"947-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antinociceptive effect of garlic, garlic preparations and derivative compounds"],"prefix":"10.1002","volume":"26","author":[{"given":"Estefani Yaquelin","family":"Hern\u00e1ndez\u2010Cruz","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  CDMX M\u00e9xico"},{"name":"Posgrado en Ciencias Biol\u00f3gicas Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  CDMX M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alfredo","family":"Silva\u2010Islas","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Vascular Cerebral Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez  CDMX M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla D.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Vascular Cerebral Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Su\u00e1rez  CDMX M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pedraza\u2010Chaverri","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  CDMX M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena Ibeth","family":"Carballo\u2010Villalobos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  CDMX M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.977248"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051415"},{"key":"e_1_2_7_4_1","first-page":"1585","article-title":"Volatile compounds of fresh and processed garlic (Review)","volume":"19","author":"Abe K.","year":"2019","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb43010016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v17i11.3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.716S"},{"key":"e_1_2_7_8_1","first-page":"2507","article-title":"Prevalence of symptomatic knee, hand, and hip osteoarthritis in Greece. 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