{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:57:21Z","timestamp":1747148241281,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The current study aimed to identify patients presenting with acute pain who may be at risk for a complicated trajectory, via identifying clusters of early opioid prescribing patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>National Veterans Affairs administrative data were utilized to build a cohort of outpatients with acute pain presentations and no more than minimal opioid use in the prior year. Latent Class Analyses (LCAs) identified clusters of early opioid prescribing patterns. The risk of progression to long\u2010term opioid use was contrasted between LCA clusters using log\u2010binomial regression, adjusting for confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2018 cohort included <jats:italic>N<\/jats:italic>\u00a0=\u00a0191,283. Among the 27,890 who received an initial opioid prescription, LCA classes were identified using: first supply day, total days dispensed across 30\u2009days, opioid type, dose and number of prescriptions across the first 30\u2009days. In the three\u2010class model: class 1 indicated an immediate, low\u2010dose and brief supply; class 2 included delayed, low\u2010dose and longer duration prescriptions and class 3 included delayed, high\u2010dose and moderate duration prescriptions. Adjusted relative risk ratios for progression to long\u2010term opioid use in the following year were 3.33 (95% CI: 2.71\u20134.10) for class 1 (absolute risk 1.1%); 7.76 (95% CI: 6.69\u20138.99) for class 2 (3.1%) and 6.81 (95% CI: 5.72\u20138.12) for class 3 (2.4%) compared to patients who did not receive an acute opioid prescription (0.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These clusters of acute opioid prescribing could facilitate the identification of patients who may benefit from enhanced pain care earlier in the pain trajectory and decrease future reliance on long\u2010term opioid therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.1980","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T05:51:57Z","timestamp":1653371517000},"page":"1523-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Opioid prescribing patterns for acute pain"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-4609","authenticated-orcid":false,"given":"Katherine","family":"Hadlandsmyth","sequence":"first","affiliation":[{"name":"Center for Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System  Iowa City Iowa USA"},{"name":"Office of Rural Health, Veterans Rural Health Resource Center, Iowa City VA Health Care System  Iowa City Iowa USA"},{"name":"Carver College of Medicine, Department of Anesthesia University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary J.","family":"Mosher","sequence":"additional","affiliation":[{"name":"Center for Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System  Iowa City Iowa USA"},{"name":"Office of Rural Health, Veterans Rural Health Resource Center, Iowa City VA Health Care System  Iowa City Iowa USA"},{"name":"Department of Internal Medicine, Carver College of Medicine University of Iowa  Iowa City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine O.","family":"Bayman","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, Department of Anesthesia University of Iowa  Iowa City Iowa USA"},{"name":"College of Public Health, Department of Biostatistics University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine G.","family":"Mares","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, Department of Anesthesia University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie S.","family":"Odom","sequence":"additional","affiliation":[{"name":"Center for Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Lund","sequence":"additional","affiliation":[{"name":"Center for Access and Delivery Research and Evaluation (CADRE), Iowa City VA Health Care System  Iowa City Iowa USA"},{"name":"Office of Rural Health, Veterans Rural Health Resource Center, Iowa City VA Health Care System  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Affairs D.o.V. and D.o. 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