{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:19:34Z","timestamp":1792009174798,"version":"4.4.0"},"reference-count":81,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_169250"],"award-info":[{"award-number":["320030_169250"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Central sensitization is considered a key mechanism underlying neuropathic pain (NP) after spinal cord injury (SCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two novel proxies for central sensitization were investigated in thoracic SCI subjects with (SCI\u2010NP) and without NP (SCI\u2010nonNP) compared to healthy controls (HC). Specifically, temporal summation of pain (TSP) was investigated by examining pain ratings during a 2\u2010min tonic heat application to the volar forearm. Additionally, palmar heat\u2010induced sympathetic skin responses (SSR) were recorded in order to reveal changes in pain\u2010autonomic interaction above the lesion level. Pain extent was assessed as the percentage of the body area and the number of body regions being affected by NP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Enhanced TSP was observed in SCI\u2010NP (+66%) compared to SCI\u2010nonNP (\u221275%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.009) and HC (\u221259%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.021). In contrast, no group differences were found (<jats:italic>p<\/jats:italic>\u00a0=\u20090.685) for SSR habituation. However, pain extent in SCI\u2010NP was positively correlated with deficient SSR habituation (body area: <jats:italic>r<\/jats:italic>\u00a0=\u20090.561, <jats:italic>p<\/jats:italic>\u00a0=\u20090.024; body regions: <jats:italic>r<\/jats:italic>\u00a0=\u20090.564, <jats:italic>p<\/jats:italic>\u00a0=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results support the value of TSP and heat\u2010induced SSRs as proxies for central sensitization in widespread neuropathic pain syndromes after SCI. Measures of pain\u2010autonomic interaction emerged as a promising tool for the objective investigation of sensitized neuronal states in chronic pain conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We present two surrogate readouts for central sensitization in neuropathic pain following SCI. On the one hand, temporal summation of tonic heat pain is enhanced in subjects with neuropathic pain. On the other hand, pain\u2010autonomic interaction reveals potential advanced measures in chronic pain, as subjects with a high extent of neuropathic pain showed diminished habituation of pain\u2010induced sympathetic measures. A possible implication for clinical practice is constituted by an improved assessment of neuronal hyperexcitability potentially enabling mechanism\u2010based treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2028","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:09:35Z","timestamp":1661476175000},"page":"2162-2175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Indicators of central sensitization in chronic neuropathic pain after spinal cord injury"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-693X","authenticated-orcid":false,"given":"Robin","family":"L\u00fctolf","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich 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