{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:38:46Z","timestamp":1791376726562,"version":"4.3.2"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013040","name":"Trigeminal Neuralgia Association of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trigeminal neuralgia (TN) is an excruciating unilateral facial pain, which negatively affects patient's quality of life. Historically, it has been difficult to compare treatment efficacy due to the lack of standardized outcomes. In addition, patients' perspective has seldomly been acknowledged. The aim of this study was to reach consensus on what outcomes of treatment are important to different TN stakeholders (patients, clinicians and researchers), to identify the TN Core Outcome Set (TRINCOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A list of outcomes identified through a systematic review and focus group work was used to develop the survey questionnaire. A three\u2010round Delphi was conducted. Participants were asked to score the outcomes on scale from 1 to 9 (1\u20133 not important;4\u20136 important but not critical;7\u20139 critical). Outcomes scored as critical by \u226570% and not important by &lt;15% were retained, and those for which no consensus was reached were discussed at a consensus meeting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 70 participants who completed the Delphi, 26 were patients, 38 were clinicians and six were researchers. Of the 40 outcomes presented, 17 were scored as critical and no consensus was met for 23 outcomes. Agreement was reached during a consensus meeting on 10 outcomes across six domains (pain, side effects, social impact, quality of life, global improvement, and satisfaction with treatment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementation of TRINCOS in future clinical trials will improve homogeneity of studies' results, reduce the redundancy in the outcome assessment and effectively allow comparison of different treatments to better inform researchers, clinicians and most importantly patients, about the efficacy of the different treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Implementation of a 10\u2010item core outcome set in trigeminal neuralgia will improve comparability between studies allowing patients to have faster access to better treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2041","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:38:47Z","timestamp":1663807127000},"page":"86-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["An international Delphi survey and consensus meeting to define the core outcome set for trigeminal neuralgia clinical trials"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-7083","authenticated-orcid":false,"given":"Carolina","family":"Venda Nova","sequence":"first","affiliation":[{"name":"University College London Eastman Dental Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richeal","family":"Ni Riordain","sequence":"additional","affiliation":[{"name":"University College London Eastman Dental Institute  London UK"},{"name":"Cork University Dental School and Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Baker","sequence":"additional","affiliation":[{"name":"School of Clinical Dentistry Sheffield University  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M.","family":"Zakrzewska","sequence":"additional","affiliation":[{"name":"University College London Eastman Dental Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261937"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010016\u20101479\u2010x"},{"key":"e_1_2_10_5_1","unstructured":"COMET. (2022).Delphi Manager. Available from:https:\/\/www.comet\u2010initiative.org\/delphimanager\/index.html."},{"key":"e_1_2_10_6_1","unstructured":"COSMIN. (2005).COnsensus\u2010based Standards for the selection of health Measurement Instruments. Available from:https:\/\/www.cosmin.nl\/."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2008.02185.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2016.02.014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)30034\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7547.969"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369\u20107625.2010.00647.x"},{"key":"e_1_2_10_12_1","volume-title":"Quality of life: The assessment, analysis and interpretation of patient\u2010reported outcomes","author":"Fayers P. M.","year":"2016"},{"key":"e_1_2_10_13_1","unstructured":"GorstS. L. BarringtonH. BrookesS. T. ChalmersJ. R. DevaneD. FledderusA. C. GrossklegS. Hall D. A. HarmanN. L. HoffmannC. KatiriR. MaesoR. SaldanhaI. J. TongA. &WilliamsonPR. (2021).Online consensus meetings for COS development: Issues to consider.https:\/\/comet\u2010initiative.org\/Downloads\/Issues%20to%20consider%20for%20online%20consensus%20meetings.pdf"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010043242"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823"},{"key":"e_1_2_10_16_1","volume-title":"The Delphi technique in nursing and Health Research","author":"Keeney S.","year":"2010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002148"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.181097"},{"key":"e_1_2_10_19_1","volume-title":"Digital uptake, usage and skills, in OECD digital economy outlook","author":"OECD","year":"2020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.im.2003.11.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100830"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010016\u20101555\u20102"},{"key":"e_1_2_10_23_1","unstructured":"RCS. (2021).Guidelines for the management of trigeminal neuralgia. Faculty of Dental Surgery Royal College Surgeons of England.https:\/\/www.google.com\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwibte22y636AhVNXcAKHQVhDbMQFnoECBIQAQ&url=https%3A%2F%2Fwww.rcseng.ac.uk%2F\u2010%2Fmedia%2Ffiles%2Frcs%2Ffds%2Fguidelines%2Ftrigemina\u2010neuralgia\u2010guidelines_2021_v4.pdf&usg=AOvVaw1Ei2iMTTekZyHNCoBpyoVy"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.28945\/199"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/cts.2019.435"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.08.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wnsx.2020.100070"},{"key":"e_1_2_10_28_1","article-title":"\u201cThey could have cut my head off and I wouldn't have cared\u201d \u2010 a qualitative study of patients' experiences and the impact of trigeminal neuralgia","author":"Venda Nova C.","journal-title":"Journal of Oral & Facial Pain and Headache"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1779"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1978-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106215\u201013\u2010132"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010018\u20103045\u20101"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000853"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.2041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.2041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.2041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:54:10Z","timestamp":1692438850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.2041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,4]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ejp.2041"],"URL":"https:\/\/doi.org\/10.1002\/ejp.2041","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,4]]},"assertion":[{"value":"2022-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}