{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:41:38Z","timestamp":1778658098025,"version":"3.51.4"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prolonged and repeated sensorimotor training is a crucial driver for promoting use\u2010dependent plasticity, but also a main risk factor for developing musculoskeletal pain syndromes, yet the neural underpinnings that link repetitive movements to abnormal pain processing are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty healthy musicians, one of the best in vivo models to study use\u2010dependent plasticity, and 20 healthy non\u2010musicians were recruited. Perceptual thresholds, reaction times (RTs) and event\u2010related potentials (ERPs) were recorded using nociceptive intra\u2010epidermal and non\u2010nociceptive transcutaneous electrical stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In response to comparable stimulus intensities, musicians compared to non\u2010musicians showed larger non\u2010nociceptive N140 (associated with higher activation of regions within the salience network), higher nociceptive N200 ERPs (associated with higher activation of regions within the sensorimotor network) and faster RTs to both stimuli. Non\u2010musicians showed larger non\u2010nociceptive P200 ERP. Notably, a similar P200 component prominently emerged during nociceptive stimulation in non\u2010musicians. Across participants, larger N140 and N200 ERPs were associated with RTs, whereas the amount of daily practice in musicians explained non\u2010nociceptive P200 and nociceptive P300 ERPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These novel findings indicate that the mechanisms by which extensive sensorimotor training promotes use\u2010dependent plasticity in multisensory neural structures may also shape the neural signatures of nociceptive processing in healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Repetitive sensorimotor training may increase the responsiveness of nociceptive evoked potentials. These novel data highlight the importance of repetitive sensorimotor practice as a contributing factor to the interindividual variability of nociceptive\u2010related potentials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.2057","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T09:38:52Z","timestamp":1668677932000},"page":"257-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extensive sensorimotor training enhances nociceptive cortical responses in healthy individuals"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4599-1552","authenticated-orcid":false,"given":"Anna M.","family":"Zamorano","sequence":"first","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology Aalborg University  Aalborg 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