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Participants were randomly assigned to Sham\u2010tDCS (<jats:italic>N<\/jats:italic>\u00a0=\u00a020 with pain, <jats:italic>N<\/jats:italic>\u00a0=\u00a020 without) or Active\u2010tDCS (<jats:italic>N<\/jats:italic>\u00a0=\u00a020 with pain, <jats:italic>N<\/jats:italic>\u00a0=\u00a020 without) targeting simultaneously the primary motor cortex and dorsolateral prefrontal cortex for 20 min with 2\u2009mA stimulation intensity. Central pain mechanisms were assessed by cuff algometry on the legs measuring pressure pain sensitivity, temporal summation of pain (TSP) and conditioned pain modulation (CPM), at baseline and after HD\u2010tDCS on Day 2 and Day 3. Based on subject's assessment of received HD\u2010tDCS (sham or active), they were effectively blinded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with Sham\u2010tDCS, Active\u2010tDCS did not significantly reduce the average NGF\u2010induced pain intensity. Tonic pain\u2010induced temporal summation at Day 2 and Day 3 was significantly lower in the NGF\u2010pain group under Active\u2010tDCS compared to the pain group with Sham\u2010tDCS (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05). No significant differences were found in the cuff pressure pain detection\/tolerance thresholds or CPM effect across the 3\u2009days of HD\u2010tDCS in any of the four groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HD\u2010tDCS reduced the facilitation of TSP caused by tonic pain suggesting that efficacy of HD\u2010tDCS might depend on the presence of sensitized central pain mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2060","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:27:23Z","timestamp":1669897643000},"page":"303-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modulation of central pain mechanisms using high\u2010definition transcranial direct current stimulation: A double\u2010blind, sham\u2010controlled 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