{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:24:15Z","timestamp":1789647855983,"version":"4.0.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New\u2010onset chronic pain has been acknowledged as part of the post\u2010COVID\u201019 condition. However, available fine\u2010grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post\u2010COVID\u201019 pain and their epidemiological and phenotypical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cross\u2010sectional study enrolled post\u2010COVID\u201019 condition patients (i.e. who had persisting COVID\u201019\u2010related symptoms over 30\u2009days since their first positive laboratory test), whose COVID\u201019 diagnosis had been supported by RT\u2010PCR of oral\/nasopharyngeal swab or serology. They underwent in\u2010person evaluations with a structured interview, pain and quality\u2010of\u2010life\u2010related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to <jats:italic>IASP<\/jats:italic> criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present study included 226 individuals, 177 (78.3%) of whom presented over 3\u2009months since their first COVID\u201019 symptom. New\u2010onset pain occurred in 170 (75.2%) participants and was chronic in 116 (68.2%). A chronic course was associated with COVID\u201019\u2010related hospitalization, new\u2010onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality\u2010of\u2010life levels. Probable NP occurred in only 7.6% new\u2010onset pain patients, and was associated with pain chronification, new\u2010onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS\u2010CoV\u20102 vaccination. Previous CP was reported by 86 (38.1%) individuals and had aggravated after the infection in 66 (76.7%) of them, which was associated with orthostatic hypotension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>COVID\u201019\u2010related pain usually follows a chronic course and is non\u2010neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechanisms, which may have significant prognostic and therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2094","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T12:30:40Z","timestamp":1676637040000},"page":"636-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pain paths among post\u2010COVID\u201019 condition subjects: A prospective cross\u2010sectional study with in\u2010person evaluation"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-8111","authenticated-orcid":false,"given":"Gabriel T.","family":"Kubota","sequence":"first","affiliation":[{"name":"LIM\u201062, Pain Center, Department of Neurology University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Pain Treatment Center Sao Paulo State Cancer Institute  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0497-2248","authenticated-orcid":false,"given":"Felipe H. 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