{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:35:49Z","timestamp":1774712149563,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged opioid use (more than 90\u2009days) after injury puts the patient at risk for adverse effects. We investigated the patterns of opioid prescription after distal radius fracture and the effect of pre\u2010 and post\u2010fracture factors on the risk for prolonged use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This register\u2010based cohort study uses routinely collected health care data, including purchases of prescription opioids, in the county of Sk\u00e5ne, Sweden. 9369 adult patients with a radius fracture diagnosed 2015\u20132018 were followed for 1\u2009year after fracture. We calculated proportions of patients with prolonged opioid use, both in total and according to different exposures. Using modified Poisson regression, we calculated adjusted risk ratios for the following exposures: previous opioid use, mental illness, consultation for pain, surgery for distal radius fracture and occupational\/physical therapy after fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prolonged opioid use (4\u20136\u2009months after fracture) was found in 664 (7.1%) of the patients. A previous, but discontinued, regular use of opioids up to 5\u2009years before fracture increased the risk compared to opioid\u2010na\u00efve patients. Both regular and non\u2010regular opioid use the year before fracture increased the risk. The risk was also higher for patients with mental illness, and those who were treated with surgery, we found no significant effect of pain consultation in previous year. Occupational\/physical therapy lowered the risk for prolonged use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considering history of mental illness and previous opioid use while promoting rehabilitation can be important to prevent prolonged opioid use after distal radius fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We show that a common injury such as distal radius fracture can be a gateway to prolonged opioid use, especially among patients with previous history of opioid use or mental illness. Importantly, previous opioid use as far back as 5\u2009years earlier greatly increases the risk of regular use after the reintroduction of opioids. Considering past use is important when planning treatment with opioids. Occupational or physical therapy after injury is associated with lower risk of prolonged use and should be encouraged.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2114","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T08:29:35Z","timestamp":1679905775000},"page":"848-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prolonged opioid use after distal radius fracture"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-8294","authenticated-orcid":false,"given":"Fabian","family":"Larrosa\u00a0Pardo","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Division of Orthopaedics, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Research and Development Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Intensive and Perioperative Care Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0661-8242","authenticated-orcid":false,"given":"Elisabeth","family":"Bondesson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Orthopaedics, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Neurosurgery and Pain Rehabilitation Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-1892","authenticated-orcid":false,"given":"Ingemar F.","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Research and Development Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5486-7556","authenticated-orcid":false,"given":"Maria E. C.","family":"Schelin","sequence":"additional","affiliation":[{"name":"Department of Research and Development Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Institute for Palliative Care Lund University and Region Sk\u00e5ne  Lund Sweden"},{"name":"Faculty of Medicine, Division of Oncology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-4911","authenticated-orcid":false,"given":"A.","family":"J\u00f6ud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Orthopaedics, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Research and Development Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Faculty of Medicine, Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"American Academy of Orthopaedic Surgeons. 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