{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:43:03Z","timestamp":1771332183244,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["320360"],"award-info":[{"award-number":["320360"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic pain and mental disorders are leading causes of disability worldwide. Individuals with chronic pain are more likely to experience mental disorders compared to individuals without chronic pain, but large\u2010scale estimates are lacking. We aimed to calculate overall prevalence of mental health diagnoses from primary and secondary care among individuals treated for chronic pain in 2019 and to compare prevalence among chronic pain patients receiving opioid versus non\u2010opioid analgesics, according to age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It is a population\u2010based cohort study. Linked data from nationwide health registers on dispensed drugs and diagnoses from primary (ICPC\u20102) and secondary (ICD\u201010) health care. Chronic pain patients were identified as all patients over 18\u2009years of age filling at least one prescription of an analgesic reimbursed for non\u2010malignant chronic pain in both 2018 and 2019 (<jats:italic>N<\/jats:italic>\u2009=\u2009139,434, 69.3% women).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of any mental health diagnosis was 35.6% (95% confidence interval: 35.4%\u201335.9%) when sleep diagnoses were included and 29.0% (28.8%\u201329.3%) when excluded. The most prevalent diagnostic categories were sleep disorders (14% [13.8%\u201314.2%]), depressive and related disorders (10.1% [9.9%\u201310.2%]) and phobia and other anxiety disorders (5.7% [5.5%\u20135.8%]). Prevalence of most diagnostic categories was higher in the group using opioids compared to non\u2010opioids. The group with the highest overall prevalence was young women (18\u201344\u2009years) using opioids (50.1% [47.2%\u201353.0%]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mental health diagnoses are common in chronic pain patients receiving analgesics, particularly among young individuals and opioid users. The combination of opioid use and high psychiatric comorbidity suggests that prescribers should attend to mental health in addition to somatic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This large\u2010scale study with nation\u2010wide registry data supports previous findings of high psychiatric burden in chronic pain patients. Opioid users had significantly higher prevalence of mental health diagnoses, regardless of age and gender compared to users of non\u2010opioid analgesics. Opioid users with chronic pain therefore stand out as a particularly vulnerable group and should be followed up closely by their physician to ensure they receive sufficient care for both their mental and somatic symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2121","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:11:10Z","timestamp":1683119470000},"page":"884-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mental disorder prevalence in chronic pain patients using opioid versus non\u2010opioid analgesics: A registry\u2010linkage study"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-8349","authenticated-orcid":false,"given":"L. 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